ID A0A0X3S7Z5_9ACTN Unreviewed; 315 AA.
AC A0A0X3S7Z5;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=6-phosphogluconate dehydrogenase {ECO:0000313|EMBL:KUJ38011.1};
GN ORFNames=ADL25_26170 {ECO:0000313|EMBL:KUJ38011.1};
OS Streptomyces sp. NRRL F-5122.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1609098 {ECO:0000313|EMBL:KUJ38011.1, ECO:0000313|Proteomes:UP000054048};
RN [1] {ECO:0000313|Proteomes:UP000054048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL F-5122 {ECO:0000313|Proteomes:UP000054048};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUJ38011.1}.
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DR EMBL; LMWH01000240; KUJ38011.1; -; Genomic_DNA.
DR RefSeq; WP_059130280.1; NZ_LMWH01000240.1.
DR AlphaFoldDB; A0A0X3S7Z5; -.
DR OrthoDB; 3185659at2; -.
DR Proteomes; UP000054048; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000054048}.
FT DOMAIN 10..169
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 176..289
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 178
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 315 AA; 32874 MW; 1A8D94BA4B645914 CRC64;
MTHVATDRPR IGWIGAGRMG YRLASRLLDA GHDVAVYNRT RAKAEPLTEK GATVVDRPEE
LADRDVVFTM VATSPDLESV TTGPGGVLTA GNASPGVLID SSTVSAQVSA LVRAAAAKHG
TGFLAAPVSG NPKVIEAGEL TVAVSGPREV FDAVQPLLSQ LGRAVTYVGA DEVARLVKIA
HNVFLGVVTQ SLAEITVLAE KGGVTRSAFL EFLNNSVMGS VFTRYKSPAL VHLDFTPTFT
NVLLRKDFDL GLAAARELEV PMPIASATAQ LVQAAVGAGL TTEDFASLIL EQARNSGMTL
EPENVAVDDG LGGRS
//
