ID   A0A0X3SD22_9ACTN        Unreviewed;       763 AA.
AC   A0A0X3SD22;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Molybdopterin oxidoreductase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=ADL25_17020 {ECO:0000313|EMBL:KUJ41136.1};
OS   Streptomyces sp. NRRL F-5122.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1609098 {ECO:0000313|EMBL:KUJ41136.1, ECO:0000313|Proteomes:UP000054048};
RN   [1] {ECO:0000313|Proteomes:UP000054048}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL F-5122 {ECO:0000313|Proteomes:UP000054048};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mo-bis(molybdopterin guanine dinucleotide);
CC         Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC       oxidoreductase family. {ECO:0000256|ARBA:ARBA00010312}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUJ41136.1}.
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DR   EMBL; LMWH01000150; KUJ41136.1; -; Genomic_DNA.
DR   RefSeq; WP_059128598.1; NZ_LMWH01000150.1.
DR   AlphaFoldDB; A0A0X3SD22; -.
DR   OrthoDB; 5287431at2; -.
DR   Proteomes; UP000054048; Unassembled WGS sequence.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0008863; F:formate dehydrogenase (NAD+) activity; IEA:InterPro.
DR   GO; GO:0030151; F:molybdenum ion binding; IEA:InterPro.
DR   GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR   CDD; cd02787; MopB_CT_ydeP; 1.
DR   CDD; cd02767; MopB_ydeP; 1.
DR   Gene3D; 3.40.50.740; -; 1.
DR   Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR   InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR   InterPro; IPR037951; MopB_CT_YdeP.
DR   InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR   InterPro; IPR006656; Mopterin_OxRdtase.
DR   InterPro; IPR010046; Mopterin_OxRdtse_a_bac.
DR   InterPro; IPR041953; YdeP_MopB.
DR   NCBIfam; TIGR01701; Fdhalpha-like; 1.
DR   PANTHER; PTHR43105:SF4; PROTEIN YDEP; 1.
DR   PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR   Pfam; PF00384; Molybdopterin; 1.
DR   Pfam; PF01568; Molydop_binding; 1.
DR   PIRSF; PIRSF000144; CbbBc; 1.
DR   SUPFAM; SSF50692; ADC-like; 1.
DR   SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054048}.
FT   DOMAIN          118..410
FT                   /note="Molybdopterin oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00384"
FT   DOMAIN          645..751
FT                   /note="Molybdopterin dinucleotide-binding"
FT                   /evidence="ECO:0000259|Pfam:PF01568"
SQ   SEQUENCE   763 AA;  83503 MW;  62194F02578C2D01 CRC64;
     MSSIEDPSDD LSVTPPKTWA TGLPAVTHAL EYSLGQTSVR RTALTLLNVN QAKGIDCPGC
     AWPEPAPGKR HTNEYCENGA KHINDEATSR RVTRDFFREH SIAELGGMSD YWLNQQGRLT
     EPMVKRPGAT HYEPIGWDEA IGLLARELSG LDSPDEALFY VSGRLNNEAA FLLQLFARAF
     GTNNLPDCSN MCHESSGSAL QETLGIGKGS VSLDDIHDAD LVFVVGQNPG TNHPRMLSAL
     EETKRNGGRV VAVNTLPEAG LMRFKHPQRV RGVIGRGTPI ADQFLHIRAG GDLALFQALN
     RLLLDAEEAA PGTVLDHSFI RSSTTGFEDF AAQAEKTSWD DVLTATGLSR EEIERVHASV
     LRSKKIIVCW AMGLTQHKHG VPTIREIVNF LMLRGNIGRP GAGVCPVRGH SNVQGDRTMG
     VWERMPQGFL DALEREFGFT PPTRHGLDSV NGIRAMRDGS AKVFVGVAGN FVRATPDSAV
     TEAAMRRCRL TAHVSTKLNR SHTVCGDTAL ILPTLGRSDR DVQVTGEQFV TVEDSMSEVH
     ASRGKLPPAS PNLLSEVAIV SRLARRTLGD EPSIPWEDFE ADYGTIRDRI SRVVPGFEDF
     NTRVARPGGF KLPNPVNEHV FRTPSGKAVF TCNEFTMPHV PEGHLLLQTL RSHDQWNTVP
     YAPNDRYRGI HNARRVVLVN PGDLEALGIA DRDEVDLVSV WHDGTERRAE NFRVVGYPTS
     RGSAASYYPE TNVLVPLDSV ADISNCPTSK GVVVRLEAAR TPA
//