ID   A0A0X3SGW7_9ACTN        Unreviewed;       387 AA.
AC   A0A0X3SGW7;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Cysteine desulfurase {ECO:0000313|EMBL:KUJ40195.1};
GN   ORFNames=ADL25_19005 {ECO:0000313|EMBL:KUJ40195.1};
OS   Streptomyces sp. NRRL F-5122.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1609098 {ECO:0000313|EMBL:KUJ40195.1, ECO:0000313|Proteomes:UP000054048};
RN   [1] {ECO:0000313|Proteomes:UP000054048}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL F-5122 {ECO:0000313|Proteomes:UP000054048};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SIMILARITY: Belongs to the class-V pyridoxal-phosphate-dependent
CC       aminotransferase family. NifS/IscS subfamily.
CC       {ECO:0000256|ARBA:ARBA00006490}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUJ40195.1}.
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DR   EMBL; LMWH01000183; KUJ40195.1; -; Genomic_DNA.
DR   RefSeq; WP_059128963.1; NZ_LMWH01000183.1.
DR   AlphaFoldDB; A0A0X3SGW7; -.
DR   OrthoDB; 9808002at2; -.
DR   Proteomes; UP000054048; Unassembled WGS sequence.
DR   GO; GO:0031071; F:cysteine desulfurase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009058; P:biosynthetic process; IEA:UniProt.
DR   Gene3D; 1.10.260.50; -; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000192; Aminotrans_V_dom.
DR   InterPro; IPR016454; Cysteine_dSase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR11601:SF34; CYSTEINE DESULFURASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11601; CYSTEINE DESULFURYLASE FAMILY MEMBER; 1.
DR   Pfam; PF00266; Aminotran_5; 1.
DR   PIRSF; PIRSF005572; NifS; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054048}.
FT   DOMAIN          3..370
FT                   /note="Aminotransferase class V"
FT                   /evidence="ECO:0000259|Pfam:PF00266"
SQ   SEQUENCE   387 AA;  40528 MW;  B1B5948CD82B1A5A CRC64;
     MAYLDHAATT PMLPEAVEAL TAQLGITGNA SSLHASGRRA RRTVEEARET LAEALGARPS
     EVVFTSGGTE ADNLAVKGLY WSRRDADPAR TRVLSSPVEH HAVLDAVHWL GEHEGATVEY
     LPVDSYGRVR PEVLREAIAR NPEDVALVTV MWANNEIGTV MPVRELVEVA TEFAIPVHSD
     AVQAFGQVPV DFEASGLAAM TVSGHKIGGP YGIGALILGR QYSPVPVLHG GGQERHVRSG
     TLDVPAIASF AVAGRLAAEQ REWFAREIGA LRDGLIAAVR SAVPDAILGG DPVHRLPANA
     HFTFPGCEGD SLLLLLDAQG IECSTGSACT AGVAQPSHVL LATGAAPDLA RGTLRFSLGH
     TSTEADVEAV AKAIGPAVER ARTAGLT
//