ID A0A0X3T9L1_9GAMM Unreviewed; 561 AA.
AC A0A0X3T9L1;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=L-lactate permease {ECO:0000256|RuleBase:RU365092};
GN ORFNames=AVO41_00655 {ECO:0000313|EMBL:KUJ72359.1};
OS Thiomicrospira sp. WB1.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Piscirickettsiaceae; Thiomicrospira.
OX NCBI_TaxID=1685380 {ECO:0000313|EMBL:KUJ72359.1, ECO:0000313|Proteomes:UP000053531};
RN [1] {ECO:0000313|EMBL:KUJ72359.1, ECO:0000313|Proteomes:UP000053531}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WB1 {ECO:0000313|EMBL:KUJ72359.1,
RC ECO:0000313|Proteomes:UP000053531};
RA Shamseldin A., Moawad H., Abd El-Rahim W.M., Sadowsky M.J.;
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Uptake of L-lactate across the membrane. Can also transport
CC D-lactate and glycolate. {ECO:0000256|RuleBase:RU365092}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|RuleBase:RU365092}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU365092}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the lactate permease family.
CC {ECO:0000256|ARBA:ARBA00010100, ECO:0000256|RuleBase:RU365092}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUJ72359.1}.
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DR EMBL; LQBN01000001; KUJ72359.1; -; Genomic_DNA.
DR RefSeq; WP_068581100.1; NZ_LQBN01000001.1.
DR AlphaFoldDB; A0A0X3T9L1; -.
DR STRING; 1685380.AVO41_00655; -.
DR OrthoDB; 9761056at2; -.
DR Proteomes; UP000053531; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR003804; Lactate_perm.
DR NCBIfam; TIGR00795; lctP; 1.
DR PANTHER; PTHR30003:SF0; GLYCOLATE PERMEASE GLCA; 1.
DR PANTHER; PTHR30003; L-LACTATE PERMEASE; 1.
DR Pfam; PF02652; Lactate_perm; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU365092};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365092};
KW Reference proteome {ECO:0000313|Proteomes:UP000053531};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365092};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365092};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365092}.
FT TRANSMEM 6..23
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 128..150
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 183..210
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 248..265
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 366..388
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 408..427
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 457..476
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 497..521
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 541..559
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
SQ SEQUENCE 561 AA; 59347 MW; 26196B17BB7E8074 CRC64;
MTLMQGLTAA MPVLAVLVFL VMLRLPASRA MPLSLLLVAA LAWQVWGMPV DYIAASVLEG
WVIGAAILII VFGAIVLLNT LKVSGAVDTI RQGFSGISPD RRVQTVIVGW LFVAFLEGAS
GFGTPAAIVA PLLMALGFPA LAAVTLALIA DSAAVSYGAV GTPVIVGIGE GVEGITYQQM
MEVAVTASLI DVMVASFLPL LMVMLLTRFF GENRSWREGL GAWKFALLGG FSFTLPALGV
AWLLGPEFPA ILGGLIGLVI TVTAARHHFL TPKTVWGFAS DTPQTAQSLH KPTPGLVKIQ
GCEKTPALSC LAVEPVRHHC LPLWQAWMPY VLVAAVLVLT RLEVLPLKDW LQGVEWQFPR
LLGTEISASL APLYLPGSVF VVIALLTWAL HRVPARQIGL AWGRSFRVLV PTVIALAASV
PMVRIFLNSG ENAAELASMP LALAQLAAET FAGQWPLAAP FVGALGSFVA GSATFSNMMF
SQLQASTAEA LSMPSHWILA LQMLGANAGN MICVVNVVAA ASVVNLAGKE GQIIRYTLGP
MLFYATAVGA VAWGLMQWLP V
//
