ID A0A0X3TY10_9RHOB Unreviewed; 1047 AA.
AC A0A0X3TY10;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Efflux pump membrane transporter {ECO:0000256|RuleBase:RU364070};
GN ORFNames=AVO45_06010 {ECO:0000313|EMBL:KUJ80597.1};
OS Ruegeria marisrubri.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Ruegeria.
OX NCBI_TaxID=1685379 {ECO:0000313|EMBL:KUJ80597.1, ECO:0000313|Proteomes:UP000053791};
RN [1] {ECO:0000313|EMBL:KUJ80597.1, ECO:0000313|Proteomes:UP000053791}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ZGT118 {ECO:0000313|EMBL:KUJ80597.1,
RC ECO:0000313|Proteomes:UP000053791};
RA Shamseldin A., Moawad H., Abd El-Rahim W.M., Sadowsky M.J.;
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU364070}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC ECO:0000256|RuleBase:RU364070}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942,
CC ECO:0000256|RuleBase:RU364070}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUJ80597.1}.
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DR EMBL; LQBQ01000012; KUJ80597.1; -; Genomic_DNA.
DR RefSeq; WP_068346025.1; NZ_LQBQ01000012.1.
DR AlphaFoldDB; A0A0X3TY10; -.
DR STRING; 1685379.AVO45_06010; -.
DR OrthoDB; 9807350at2; -.
DR Proteomes; UP000053791; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF78; CATION OR DRUG EFFLUX SYSTEM PROTEIN; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU364070};
KW Cell membrane {ECO:0000256|RuleBase:RU364070};
KW Membrane {ECO:0000256|RuleBase:RU364070};
KW Reference proteome {ECO:0000313|Proteomes:UP000053791};
KW Transmembrane {ECO:0000256|RuleBase:RU364070};
KW Transmembrane helix {ECO:0000256|RuleBase:RU364070};
KW Transport {ECO:0000256|RuleBase:RU364070}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 342..361
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 368..389
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 436..460
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 472..499
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 531..553
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 863..884
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 896..915
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 921..946
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 967..986
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 998..1022
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
SQ SEQUENCE 1047 AA; 110586 MW; 91E77F93523F133D CRC64;
MFSALFISRP KLALVISLVL TIMGMIGYTV LPVAQFPDIT PPVVSVSANY TGANAGTVEN
TVAAPIEAQV NGVDDMIYMT STSSDNGAYS LNVTFEVGTD PDIASVNVQN RVAQAMASLP
TEVTASGVVT EKASTNMLLV VTLTSPNGTY DSVFLSNYAS INLKDALARV QGVGKADVLT
NLEYAMRVWM DPDRMAALSI TPGDVINAIR EQNVEVSAGS IGAPPAPEGQ TFQYTIKTQG
RLTTPEEFGN IVVRAGDAGS IVRVKDIGKV ELGAEFYAAS GFFQGQPATV LGIYQAPGAN
ALAVSERVRA ELERLSRAFP SDVEYQVPFD TTDFVEQSLN DVVSTLVMTF ILVISVVFVF
LGNWRATVIP AVAIPVSLIG TFAFLLLFGM SLNTISLFAL VLAIGIVVDD AIVVVENVER
IIAEEGLSPP EATRKAMGQI TGPVIATTLV LLAVFVPVTF MPGISGRLYS QFAVTISTAV
VISSINALTL SPALCGLVLK PRSGPPKGLL ALFEGLIGTV RSGYVSIVRM LLVIPVVSIG
IIVLIAMGAG TIMSNTSKGF IPLEDNGYLF VDVQLPDAAT LTRTEVVTAR VNEKLSAIPG
VANTVLVNGF SLLNGLTPNG AMIIVNLDNW DDRQDEDLSA DAILQKVLGV AYGESAASIV
AFNPPPIQGL GMSAGVEMEV QQTGGGSPQD LAAAVGSLVY SANQRPEIAQ AFTTFRANVP
QLFVDLDREK AKTLQVSVGE IFQTMQAQLG SFYVNDFNLF GRVYRVMIQA EGSYRDKVDD
ISNLWVRSTK GEMVPLGTLV DVENVLGPVL LKRHNLFRSA TVTAVQAEGL STGDAIRVMT
EESATALPPG YAFEWTGTAQ QQLASGGLVV VILGLAILFG YLFLVGQYES WSMPVAILLS
VIVALFGAVA AVAIVGSDIN LYTQIGMIML VGLASKNGIL IVEFAMEQRA HGLSIRDAAA
EAAHQRFRAV MMTALSFLLG VVPLMLANGA GAASQKAIGF AVFGGMLAAT VVGVVLVPVL
YATMQGFREW IKGIGKKDPA TTEDTAA
//
