ID A0A0X3UNE5_9ACTN Unreviewed; 560 AA.
AC A0A0X3UNE5;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=IclR family transcriptional regulator {ECO:0000313|EMBL:KUL34138.1};
GN ORFNames=ADL12_20850 {ECO:0000313|EMBL:KUL34138.1};
OS Streptomyces regalis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=68262 {ECO:0000313|EMBL:KUL34138.1, ECO:0000313|Proteomes:UP000053923};
RN [1] {ECO:0000313|Proteomes:UP000053923}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 3151 {ECO:0000313|Proteomes:UP000053923};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL34138.1}.
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DR EMBL; LLZG01000173; KUL34138.1; -; Genomic_DNA.
DR RefSeq; WP_062704186.1; NZ_LLZG01000173.1.
DR AlphaFoldDB; A0A0X3UNE5; -.
DR OrthoDB; 9807558at2; -.
DR Proteomes; UP000053923; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046278; P:3,4-dihydroxybenzoate metabolic process; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.30.450.40; -; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR012794; PcaR_PcaU.
DR InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR02431; pcaR_pcaU; 1.
DR PANTHER; PTHR30136; HELIX-TURN-HELIX TRANSCRIPTIONAL REGULATOR, ICLR FAMILY; 1.
DR PANTHER; PTHR30136:SF34; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR Pfam; PF09339; HTH_IclR; 2.
DR Pfam; PF01614; IclR; 2.
DR SMART; SM00346; HTH_ICLR; 2.
DR SUPFAM; SSF55781; GAF domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51077; HTH_ICLR; 2.
DR PROSITE; PS51078; ICLR_ED; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053923};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 18..85
FT /note="HTH iclR-type"
FT /evidence="ECO:0000259|PROSITE:PS51077"
FT DOMAIN 79..273
FT /note="IclR-ED"
FT /evidence="ECO:0000259|PROSITE:PS51078"
FT DOMAIN 302..363
FT /note="HTH iclR-type"
FT /evidence="ECO:0000259|PROSITE:PS51077"
FT DOMAIN 364..550
FT /note="IclR-ED"
FT /evidence="ECO:0000259|PROSITE:PS51078"
FT REGION 171..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 560 AA; 60271 MW; 9C4D5EDBBEA5CE98 CRC64;
MPAKTTMDAA PAVPAEAVTP LIRGVAVLRQ LTEAGGTLSA SGLERATGLA RSTVDRIAST
LARMGYVRLD GRDVVLAPRV MELGNAYLAA LGMPALLSSH ADALADELDE SVSLAVADRD
GIRFIHQATR RRAMSLSFRI GDLLPAERTA PGPLFAAEWT DAEWQTWRER RAADPQDRDF
PAVPPREHAL SDEDFERRAQ RARKDGWALD DQLIEPGLVA VSVPVRDPRA GGRIACVANV
VSHTSRHTAA NLRDTLLPRL RTAVAKMERE LREAPQPQPG AAPAGLAIWT GASKQELGRE
FVESLARGLT VLTAFGEGRA ELTLTDVARA TGLARATARR ALITYEYLGL VRQSGNRGFT
LTPRVLSLGY PPLSRTSLSQ IAAPHLAELA DRVHESASLA VLTPSGEEIQ YTARAATHRV
MSVNITVGTR LPAYATSLGR VLLADTPAGE RQLAAALGEL HPLTPRTITD PSALATVLED
IRKRGYALVD EELEEGLRSV AVPVRDRTGR VVAAVNVAMH AARWSMEECV RDVLPELVET
AGRVEGDLRV AGRFARVSVS
//
