ID A0A0X3UY59_9ACTN Unreviewed; 640 AA.
AC A0A0X3UY59;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Succinate dehydrogenase {ECO:0000313|EMBL:KUL37451.1};
DE EC=1.3.5.1 {ECO:0000313|EMBL:KUL37451.1};
GN Name=sdhA {ECO:0000313|EMBL:KUL37451.1};
GN ORFNames=ADL22_21425 {ECO:0000313|EMBL:KUL37451.1};
OS Streptomyces sp. NRRL F-4489.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1609095 {ECO:0000313|EMBL:KUL37451.1, ECO:0000313|Proteomes:UP000053256};
RN [1] {ECO:0000313|EMBL:KUL37451.1, ECO:0000313|Proteomes:UP000053256}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL F-4489 {ECO:0000313|EMBL:KUL37451.1,
RC ECO:0000313|Proteomes:UP000053256};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL37451.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LLZI01000235; KUL37451.1; -; Genomic_DNA.
DR RefSeq; WP_066982056.1; NZ_LLZI01000235.1.
DR AlphaFoldDB; A0A0X3UY59; -.
DR STRING; 1609095.ADL22_21425; -.
DR OrthoDB; 9805351at2; -.
DR Proteomes; UP000053256; Unassembled WGS sequence.
DR GO; GO:0102040; F:fumarate reductase (menaquinone); IEA:UniProtKB-EC.
DR GO; GO:0033765; F:steroid dehydrogenase activity, acting on the CH-CH group of donors; IEA:UniProt.
DR GO; GO:0008177; F:succinate dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.20.58.100; Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain; 1.
DR Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR037099; Fum_R/Succ_DH_flav-like_C_sf.
DR InterPro; IPR015939; Fum_Rdtase/Succ_DH_flav-like_C.
DR InterPro; IPR030664; SdhA/FrdA/AprA.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR PANTHER; PTHR11632; SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT; 1.
DR PANTHER; PTHR11632:SF89; SUCCINATE DEHYDROGENASE [IRON-SULFUR SUBUNIT] (SUCCINIC DEHYDROGENASE)-RELATED; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR Pfam; PF02910; Succ_DH_flav_C; 1.
DR PIRSF; PIRSF000171; SDHA_APRA_LASPO; 1.
DR PRINTS; PR00368; FADPNR.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF46977; Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:KUL37451.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053256}.
FT DOMAIN 10..430
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
FT DOMAIN 489..586
FT /note="Fumarate reductase/succinate dehydrogenase
FT flavoprotein-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02910"
FT REGION 591..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 322
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000171-1"
SQ SEQUENCE 640 AA; 70563 MW; ADE5CE2D2A04FBF9 CRC64;
MAHVDRQTWD VVVVGAGGAG LRAAIEAREA GMRTAVICKS LFGKAHTVMA EGGIAASMGN
ANEHDTWQVH FRDTMRGGKF LNHWRMAELH AREAPDRVWE LETWGALFDR TPDGRISQRN
FGGHEYPRLA HVGDRTGLEL IRTLQQRIVA LQQEDQRVSG SYEEGLKVFQ ECTVTRVLKT
DGKVSGVFCY DRESGRFFVL EAPAVVLATG GIGKSFKVTS NSWEYTGDGH ALALLAGAPL
INMEFVQFHP TGMVWPPSVK GILVTESVRG DGGVLRNSDG KRFMFDYIPD VFKEKYAETE
AEGDRWYDDP DRNRRPPELL PRDEVARAIN AEVKAGRGSP HGGVFLDVST RMPAEVIQRR
LPSMYHQFKE LADVDITAEP MEVGPTCHYV MGGVEVDPDT AAATGVPGLF AAGEVAGGMH
GSNRLGGNSL SDLLVFGRRA GLYAAEYVTG LRARPPAEPH DIDAAEAEAL RPFSAEEAGG
PAENPYTLHQ ELQQAMNDLV GIIRREGEMS QALERLAALR ARAERAGVEG HRQYNPGWHL
ALDLRNMLLV SECVARAALT RTESRGGHTR DDYPEMDRRW RNVNLVCALA DGPGGDGDPG
PAPGRIRLTR RETPPIRRDL LELFEKDELV KYLTDEELSR
//
