ID A0A0X3V1N2_9ACTN Unreviewed; 490 AA.
AC A0A0X3V1N2;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=MFS transporter {ECO:0000313|EMBL:KUL37166.1};
GN ORFNames=ADL22_22510 {ECO:0000313|EMBL:KUL37166.1};
OS Streptomyces sp. NRRL F-4489.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1609095 {ECO:0000313|EMBL:KUL37166.1, ECO:0000313|Proteomes:UP000053256};
RN [1] {ECO:0000313|EMBL:KUL37166.1, ECO:0000313|Proteomes:UP000053256}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL F-4489 {ECO:0000313|EMBL:KUL37166.1,
RC ECO:0000313|Proteomes:UP000053256};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. Azg-like subfamily. {ECO:0000256|ARBA:ARBA00005697}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL37166.1}.
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DR EMBL; LLZI01000240; KUL37166.1; -; Genomic_DNA.
DR RefSeq; WP_066982686.1; NZ_LLZI01000240.1.
DR AlphaFoldDB; A0A0X3V1N2; -.
DR STRING; 1609095.ADL22_22510; -.
DR OrthoDB; 9808458at2; -.
DR Proteomes; UP000053256; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1904823; P:purine nucleobase transmembrane transport; IEA:UniProt.
DR InterPro; IPR045018; Azg-like.
DR InterPro; IPR006043; NCS2.
DR PANTHER; PTHR43337; XANTHINE/URACIL PERMEASE C887.17-RELATED; 1.
DR PANTHER; PTHR43337:SF1; XANTHINE_URACIL PERMEASE C887.17-RELATED; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053256};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 45..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 78..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 490 AA; 50758 MW; 5D6EEA586E1C3716 CRC64;
MSPSTPSPVD TVKSPGPQPP RNALDRFFKI SERGSTVSRE LRGGLATFFA MAYIVVLNPI
ILGAGVDKYG HHLDNGQLVT ATALMAGLGT VLMGLMGNVP IAIAAGLGIN AVVSLQLAPK
MSWPDAMGMV VLAGLVLMIL VASGLRQRVM DAIPNGLRRA IAIGIGLFIS LVGLVDAGFV
SRNPDAAHTT VPLSLGQGGQ LKGWPVLVFV LGLALMFVLT VRKTKGAILI GMVTMAVVAV
IINAVADIPD ASWGLAVPNV PHKIVGAPDF GLIGHISLFG GFREVGVLTG CLFVFTVLLS
GFFDAMGTII GVGEEAGLLD NETGNLPNMG RILMADGIAV AGGGFGSASA NTCFVESTAG
VGEGARTGLA NLVTGGLFLL ALIFTPLATV VPSQAATPAL LVVGFLIMAA NVRDIDWSDF
TVAVPAFLTL VAMPFTYSIT NGIGMGVLAY ILLRTVTGRF KEIPWLLNAV GVCFLVYFLL
NPIEQILGVK
//
