ID A0A0X3VDB6_9ACTN Unreviewed; 488 AA.
AC A0A0X3VDB6;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=ADL15_01630 {ECO:0000313|EMBL:KUL42262.1};
OS Actinoplanes awajinensis subsp. mycoplanecinus.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=135947 {ECO:0000313|EMBL:KUL42262.1, ECO:0000313|Proteomes:UP000053244};
RN [1] {ECO:0000313|EMBL:KUL42262.1, ECO:0000313|Proteomes:UP000053244}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-16712 {ECO:0000313|EMBL:KUL42262.1,
RC ECO:0000313|Proteomes:UP000053244};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL42262.1}.
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DR EMBL; LLZH01000002; KUL42262.1; -; Genomic_DNA.
DR RefSeq; WP_067684395.1; NZ_LLZH01000002.1.
DR AlphaFoldDB; A0A0X3VDB6; -.
DR OrthoDB; 1931120at2; -.
DR Proteomes; UP000053244; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR PANTHER; PTHR43065:SF48; TWO-COMPONENT SENSOR HISTIDINE KINASE-RELATED; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:KUL42262.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053244};
KW Transferase {ECO:0000313|EMBL:KUL42262.1}.
FT DOMAIN 27..135
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 304..484
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 488 AA; 53286 MW; C32C3B6AE9AF3621 CRC64;
MTEPEAITLE PCEPGRLTAE DLRSLFLFEK LTDEQLTWIA EHGCTQRVAG GGLVLREGDP
AEQFFVLLTG TVALTRRVGQ DDVQTVRTEQ RGVYMGATTA YLRDDGVPQR YMASMRALSD
SEFFTLSAAD FGWLMREWFP MAIHLLEGLT LGMRSSQAVI GERQRLQALG ALSAGLMHEL
NNPAAAASRA TGALRQRVAG MRMKLGKLAA GKVAPDRLMQ LLELQEEVIE RAAKAPSLTA
MQTADREDEL GDWMDEHGVT GGWDVAPVFA QGGIDVDCLT EIQDRLASPE LLDQAIHWIG
YALETEQLMS DIEDATGRVS SLVNAAKQYS HVDRSAHQWI DVHTGLDSTL VMLAHKIGDG
IRVVKDYDRT LPQIPVHPAE LNQVWTNLID NAVQAMSGAG TLTIRTYQED ERVVVSVGDS
GPGVPDEIKK RVFEPFFTTK PVGEGTGLGL DISYRIVVNG HGGDLSLQSA PGDTRFLVRL
PLSEPASA
//
