ID   A0A0X3VE80_9ACTN        Unreviewed;       497 AA.
AC   A0A0X3VE80;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Peptidase S8 {ECO:0000313|EMBL:KUL43111.1};
GN   ORFNames=ADL22_13625 {ECO:0000313|EMBL:KUL43111.1};
OS   Streptomyces sp. NRRL F-4489.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1609095 {ECO:0000313|EMBL:KUL43111.1, ECO:0000313|Proteomes:UP000053256};
RN   [1] {ECO:0000313|EMBL:KUL43111.1, ECO:0000313|Proteomes:UP000053256}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL F-4489 {ECO:0000313|EMBL:KUL43111.1,
RC   ECO:0000313|Proteomes:UP000053256};
RA   Gilbert D.G.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC       ECO:0000256|RuleBase:RU003355}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUL43111.1}.
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DR   EMBL; LLZI01000146; KUL43111.1; -; Genomic_DNA.
DR   RefSeq; WP_066977832.1; NZ_LLZI01000146.1.
DR   AlphaFoldDB; A0A0X3VE80; -.
DR   STRING; 1609095.ADL22_13625; -.
DR   OrthoDB; 9813435at2; -.
DR   Proteomes; UP000053256; Unassembled WGS sequence.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR   PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000053256};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..37
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           38..497
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5007055913"
FT   DOMAIN          171..488
FT                   /note="Peptidase S8/S53"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   ACT_SITE        179
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        223
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        430
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   497 AA;  51077 MW;  309651C1026FFB93 CRC64;
     MARPLAHPRK RRLRALAVPV GLALTASLGF LPGAAGAAAP ADSGPLLSYV VNTVPDHATV
     GAVERAIDRA GGKVITAHER IGVIVAHSAN PRFAATLRTT PGVQSAGATR TAPLKQTGTD
     DVGKPQRITA AQLAAAERTA KAKGGEPLEP LQWDLPAIKA DQAAKVNPGS RKVTVAVIDT
     GVDDTHPDLK PNFSARQSAN CVGGVPDTSP GAWRPYDPVE DAHGTHVAGT IAAARNGVGV
     AGVAPGVKVS AIKVSEPKTS LFYAESVVCA FVFAADHGVQ VTNNSYYVDP WMFNCKDDAD
     QAAIVDAVGR AAKYAQDKGV VNVAAAGNAN ADLAADKLTD TGSPNDSTPV TRTLSPKTCW
     DVPTQLPGTV TVAATGSHRL KSGYSNYGLN QIDVAAPGGD SKQLPDLPAK NGNILSTIPG
     GDWAFYAGTS MASPHVAGVA ALLKSAHPKA GPQEIQWLLK QQADNPGCPA TDRTCTGTPQ
     LNSHFGYGIV NALKAVE
//