ID A0A0X3VHH6_9ACTN Unreviewed; 643 AA.
AC A0A0X3VHH6;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Acetoacetyl-CoA synthetase {ECO:0000313|EMBL:KUL43702.1};
DE EC=6.2.1.16 {ECO:0000313|EMBL:KUL43702.1};
DE Flags: Fragment;
GN ORFNames=ADL22_13275 {ECO:0000313|EMBL:KUL43702.1};
OS Streptomyces sp. NRRL F-4489.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1609095 {ECO:0000313|EMBL:KUL43702.1, ECO:0000313|Proteomes:UP000053256};
RN [1] {ECO:0000313|EMBL:KUL43702.1, ECO:0000313|Proteomes:UP000053256}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL F-4489 {ECO:0000313|EMBL:KUL43702.1,
RC ECO:0000313|Proteomes:UP000053256};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL43702.1}.
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DR EMBL; LLZI01000137; KUL43702.1; -; Genomic_DNA.
DR RefSeq; WP_066977662.1; NZ_LLZI01000137.1.
DR AlphaFoldDB; A0A0X3VHH6; -.
DR Proteomes; UP000053256; Unassembled WGS sequence.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd05943; AACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:KUL43702.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053256}.
FT DOMAIN 23..79
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 94..459
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 526..601
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KUL43702.1"
SQ SEQUENCE 643 AA; 70036 MW; 298F6D71E70D586B CRC64;
FHTWAATHHG APAPLPGDPA ASYAALHRWS TDQLPAFWQA VAEWFDVRFT TPYETVLADP
AMPGARWFPG ATLNYAEHAL RAAEDPARAA TPALLAVDER QQPTPVTWAE LRAQTASLAA
ALRRLGVRPG DRVSGYLPNI PQAVTALLAT AAVGAVWTSC APDFGARSVL DRFQQVEPVV
LFTVDGYRYA GKEHDRRDTV AELRAELPTL RAVVHIPLLG TPAPEGALNW SDLIADDTEP
VYEQVPFDHP LWVLYSSGTT GLPKALVQSQ GGILLEHLKQ TGLHCDLGPG DRFFWYTSTG
WMMWNFLVGG LLAGATIVLY DGSPAHPATD AQWQIAAATR TTVFGTSAAY VMACRKAGLH
PARDLDLSTV TCVATTGSPL PPDGFRWLHD TFAEAGTDLW TASVSGGTDV CSCFAGAVPT
LPVHIGELQA PCLGTDLQAW DPYGKPVTDE VGELVVTKPM PSMPTRFWND PDGTRYHDSY
FAMYPGVWRH GDWITLTSRG SVIIHGRSDS TLNRQGVRMG SADIYEAVER LPEIRESLVI
GLELPDGGYW MPLFVHLAPG ATLDDALRDR IKRTLREQLS PRHVPDEIIE APGVPHTLTG
KRIEVPVKRL LAGTPLEKAV NPGSVDNLEL LRFYERLAAD RAT
//