ID   A0A0X3VLU0_9ACTN        Unreviewed;       481 AA.
AC   A0A0X3VLU0;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE            EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN   ORFNames=ADL12_02955 {ECO:0000313|EMBL:KUL45749.1};
OS   Streptomyces regalis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=68262 {ECO:0000313|EMBL:KUL45749.1, ECO:0000313|Proteomes:UP000053923};
RN   [1] {ECO:0000313|Proteomes:UP000053923}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 3151 {ECO:0000313|Proteomes:UP000053923};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUL45749.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LLZG01000009; KUL45749.1; -; Genomic_DNA.
DR   RefSeq; WP_062698136.1; NZ_LLZG01000009.1.
DR   AlphaFoldDB; A0A0X3VLU0; -.
DR   OrthoDB; 1931120at2; -.
DR   Proteomes; UP000053923; Unassembled WGS sequence.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 1.10.287.130; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR   PANTHER; PTHR43065:SF48; TWO-COMPONENT SENSOR HISTIDINE KINASE-RELATED; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000313|EMBL:KUL45749.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053923};
KW   Transferase {ECO:0000313|EMBL:KUL45749.1}.
FT   DOMAIN          18..124
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          292..475
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
SQ   SEQUENCE   481 AA;  52983 MW;  063A7CE48F922E77 CRC64;
     MSGQPMPCDP GEIGALFLFE KLTPEQLGRL CSEGRVELFQ PGPVYTEGDP ATCFYVMVEG
     TVVLSRRVGG DDVEVTRTSQ RGVYSGAWQA YLGDRVPQVY NSSMRVTEPT RFFVLPAATF
     AAVVQEWFPM ALHLLEGLFF GQKSTQSAIN QRERLLALGS LSAGLTHELN NPAAAAVRAT
     ATLRERVAKM RHKLAVITQG SYSPEVIANL VDIQERTAER VAKAPTLSPL EASDREDELT
     DWLEDHGIAE GWRIAPTFVQ AGLDADWLDQ IAAAVDEEIL PSAIGWLNYT VENELLMDEI
     NDSTNRISHL VDAAKQYSQL DRAPFQNADV HELLDSTLLM LSGKIGRQIK VVKEYDRTLP
     KIPAYPAELN QVWTNLIDNA VSAINDAGGE GTLTVRTAPD HDRLLVEFRD TGVGIAPEHR
     GRIFDPFFTT KPVGEGTGLG LDISWRIVVN KHHGSIQVES EPGDTRFQVL LPLTSVEEEP
     V
//