ID A0A0X3VNC3_9ACTN Unreviewed; 2362 AA.
AC A0A0X3VNC3;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:KUL46259.1};
DE Flags: Fragment;
GN ORFNames=ADL12_02510 {ECO:0000313|EMBL:KUL46259.1};
OS Streptomyces regalis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=68262 {ECO:0000313|EMBL:KUL46259.1, ECO:0000313|Proteomes:UP000053923};
RN [1] {ECO:0000313|Proteomes:UP000053923}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 3151 {ECO:0000313|Proteomes:UP000053923};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL46259.1}.
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DR EMBL; LLZG01000006; KUL46259.1; -; Genomic_DNA.
DR RefSeq; WP_062697966.1; NZ_LLZG01000006.1.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000053923; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd17646; A_NRPS_AB3403-like; 2.
DR CDD; cd19540; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 5.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053923}.
FT DOMAIN 767..842
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1814..1888
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1797..1816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KUL46259.1"
SQ SEQUENCE 2362 AA; 254645 MW; BDEC2F59875A1DCA CRC64;
LALPTDAPRT ARPAAHGDRR FHTFAPDVTE RLTAFARNAG ATPFMVLLAG LAALLHRTTS
ATDIPIGSAV MNRDLPGLEK LIGNFGNTLA LRADLEGDPG FAELVERVKQ LCTDGYAHQD
MPFDKLVEQL KPERQPGRSV YFDVMLLFLT QGLEGPQLPG VTAEWETVHN DTTQFDLSLE
AFLTGGRLRI EATYRSSLFT ADTVDRLLRH LETLLEASLS DPELAVSRLP LMTESEQHRV
VEEWNTTDRS LPAALLTDLL AQQAARTPDA PALIADDGRP GLDYAGLHAR ANRLARLLIS
HGVGPEHLVG VALDRGTDLV VALLAVLKAG AAYVPLDTGY PAERLAFMVE DAAPALVLTA
TDTARILPPG VPLLLLDTET TAFDSAEVTD ADRVRPLRPE HPAYVIYTSG STGRPKGAVV
PHAGIVNRLL WMQATYELGP GERVLQKTPA GFDVSVWEFF WPLITGAELV LARPGGHRDP
GYLAELIRDR RVTTAHFVPS MLRVFLDDPA AGQARGVLRR LVCSGEALLT ELAERCVESL
PGTELHNLYG PTEAAVDVTA WPCAEGTRSA AGSVPIGRPV WNTRTLVLED YLRPVPPGVP
GELYLGGAQL ARGYLRRPGL TAERFVADPY GPPGARLYRT GDLVRWSAQG ALEFLGRSDD
QVKIRGFRVE PGETEAAVAA LPGVSQAVVM VRQEEPGEPR LVAYAVPHPG TSLEPLQVRQ
DLKVTLPEHL LPAAVVILDG LPLTPNGKLD RGALPAPDLS GLTTATAPRT EAEAALCALF
ADLLGLPSVG IHDEFFALGG HSVLATRLVA RIGAELGAVV PLRAVFDTPT VAALAPLLEA
PDAERRPPLL PARRPDPVPL SSAQARLWFL YRLEGASPTY NIHTAVRLTG PLDTDALRAA
LHDVVARHES LRTVFPDDDG TPYQRILAKA DVPFEVVPAR ARELDALLSE AAAYSFALDA
KIPVRATLYA LAPGEHVLLL LVHHIATDGW SAEPLLRDLE TAYAARVRGG RPEWPPLAVQ
YADYTLWQRQ LLEDGGRAEV ELDYWARQLE GVPEELQLPV DRARPAVVGY RAGAVDFALD
AEVHGALRDL AAEAGGTVFM ALQAALAVLL GRLGAGDDIP LGTPVAGRGD AALDDLVGLF
VNTLVLRTDV SGDPTFRTLL ARVRETDVDA YAHQDLPFER LVDALAPARS MGRHPLFQVM
LAHQQAPDGT RDFAGLTLSE LRVDFYTAKT DLAFHVFERA DGGGITGSLL HSRDLYDEET
AQDLVERFVR LVGELARQPD LPVSLADLLT PRERALMLGE WNDTAHPMPA TTLTALVEEQ
AAKTPDLPAV EYGIEGGLTL TYAELNARAN VLAGQLTSLG VGPERCVGIH LERSVEMVVG
LLAVLKAGGA FVPLEPSWPA RRIAEVCRSA ALTAVLGKPG GAVVLGDDAP PFVEVRLDGP
ERTDNPNVPV DPEGLAYVIY TSGSTGVPKG AMIRHRAIAH RLLWQRGLLG FGTEDAALFK
APLGFDISIN EIFLPLVNGG RVVIAEPGGE RDVDYLLDTV ERHRVTFTYL VSSMLDLLLE
LDGFARRARS LKHVWCGGEV LTPELFARFR AASPAVMYHG YGPAEATIGV SHVVYRTGAI
RSAVSIGRPN GNTRLYVLDD RLQPVPVGVP GELYAGGVYL GRGYVNDACR TADHWVADPF
GPPGERLYRT GDLVRWQRDG TLEFLGRADN QVKIRGMRVE LEEIEAIVEQ HPGVRRGVAV
IREDAPGVKQ LAGYYLAADG LDDLHGWLRE RLPEHMVPRT LTALDAFPLL PSGKVDRGSL
PAPATTTSRA ATRAPADERE RQLCELFASV LGLGRVDVDD NFFELGGDSI VSIRLVTLAR
KAGIALSPRH VFQTPTPAGL AACAEPTGTG LLDEPVGEAE PTPIMRWTAG PDGSYGGLAQ
AVLLVTPPDL TYDTAVDVLQ ALLDRHDMLR ARLTNQLVVP PEGVVRASEL LSQVRDTALD
DQLAAAVARL DPAAGRMLQA VWFTDSGRLL LVAHHLVVDG VSWRIITSDL AEAWQSGRAL
LRSGTSFRTW SKLLAEEARK PERVRELARW TGELEGARPF LERDLGTAGS VREDTLVLPD
DVTAPLLTSV PAAYHAAAPD VLLTALALAA AAWRDRRGDL DGRSLLVGLE GHGREEDIAE
GVDLSATVGW FTTFHPVGID PGPLDLDEAL SGGPAAGTAL KRIKEQLRAV PDHGLGYGLL
RHLNPDTAPA LEKLPQPQIL FNYLGRFTAS GAAGEPWELA PEAPMLRVPP DRGRPAAFGL
EINAVAVEEA SGVRLHVSAS WPDGFLTESE AADLLGLWER ALRGLARHTE DAPAGGLTPS
DLPLVELTQE DIDDFENDFD DF
//