ID A0A0X3VTG0_9ACTN Unreviewed; 670 AA.
AC A0A0X3VTG0;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Squalene-hopene cyclase {ECO:0000313|EMBL:KUL47988.1};
GN ORFNames=ADL30_35230 {ECO:0000313|EMBL:KUL47988.1};
OS Streptomyces sp. NRRL S-1521.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1609100 {ECO:0000313|EMBL:KUL47988.1, ECO:0000313|Proteomes:UP000053420};
RN [1] {ECO:0000313|EMBL:KUL47988.1, ECO:0000313|Proteomes:UP000053420}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL S-1521 {ECO:0000313|EMBL:KUL47988.1,
RC ECO:0000313|Proteomes:UP000053420};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004999}.
CC -!- SIMILARITY: Belongs to the terpene synthase family.
CC {ECO:0000256|ARBA:ARBA00006333}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL47988.1}.
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DR EMBL; LLZK01000272; KUL47988.1; -; Genomic_DNA.
DR RefSeq; WP_062783095.1; NZ_LLZK01000272.1.
DR AlphaFoldDB; A0A0X3VTG0; -.
DR UniPathway; UPA00337; -.
DR Proteomes; UP000053420; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR006400; Hopene-cyclase.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01507; hopene_cyclase; 1.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000053420};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 43..328
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 339..654
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 670 AA; 73782 MW; 440F8FE7D93CB97A CRC64;
MTATTDGSTG AVTPRAASAS HSIDTPAATP PTAGTREAAA LAIQRSTDFL LSRQDAEGWW
KGDLETNVTM DAEDLLLRQF LGIGDERTTR AAALFIRGEQ REDGTWATFF GGPGELSTTI
EAYVALRLAG DLPDAPHMAR AAEWIRDRGG IAESRVFTRI WLALFGWWSW DDLPELPPEL
IYFPPWVPLN IYDFGCWARQ TIVPLTVVSA KRPVRPAPFA LDELHVDARV PRPPKPLAPA
TSWDGLFERL DKALHVYHKV APRRLRGAAM NSAARWIIER QENDGCWGGI QPPAVYSIIA
LHLLGYDLEH PVLKAGLASL DRFAVWREDG ARMIEACQSP VWDTCLATIA LADAGLPADH
PQLVRAADWM LGEEIVRPGD WAVRKPRLAP GGWAFEFHND NYPDIDDTAE VALALRRVAH
PDQARVDNAI ARGMRWTLGM QSKNGAWAAF DADNTSPFPN RLPFCDFGEV IDPPSADVTG
HVVEMLAVEG RSHDPRTRRG IEWLLAEQED NGAWFGRWGV NYLYGTGSVV PALITAGLPA
SHAAIRRAVR WVESVQNDDG GWGEDLRSYR DRGWVGHGTS TASQTAWALL TLLSAGEREA
PSVERGIAWL AATQRPDGSW DEPYFTGTGF PWDFSINYHL YRQVFPLTAL GRYVNGEPFP
AGSAHAGKGS
//
