ID A0A0X3XJW6_9ACTN Unreviewed; 1101 AA.
AC A0A0X3XJW6;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Peptidase S8 {ECO:0000313|EMBL:KUL69663.1};
GN ORFNames=ADL34_28755 {ECO:0000313|EMBL:KUL69663.1};
OS Streptomyces sp. NRRL WC-3605.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1609103 {ECO:0000313|EMBL:KUL69663.1, ECO:0000313|Proteomes:UP000052945};
RN [1] {ECO:0000313|EMBL:KUL69663.1, ECO:0000313|Proteomes:UP000052945}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL WC-3605 {ECO:0000313|EMBL:KUL69663.1,
RC ECO:0000313|Proteomes:UP000052945};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240, ECO:0000256|RuleBase:RU003355}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL69663.1}.
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DR EMBL; LLZN01000091; KUL69663.1; -; Genomic_DNA.
DR RefSeq; WP_062671599.1; NZ_LLZN01000091.1.
DR AlphaFoldDB; A0A0X3XJW6; -.
DR OrthoDB; 9798386at2; -.
DR Proteomes; UP000052945; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR017297; Peptidase_S8A_DPH-A.
DR PANTHER; PTHR43399; SUBTILISIN-RELATED; 1.
DR PANTHER; PTHR43399:SF4; TK-SUBTILISIN; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PIRSF; PIRSF037854; Dihydropyridine_esterase; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000052945};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..1101
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007058037"
FT DOMAIN 218..482
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT REGION 25..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 227
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 259
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 436
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1101 AA; 114533 MW; 467A14DEDA3436C6 CRC64;
MRRHVRRACA AAVASAAALA LTAGTTGPAS AQPERRPSGA ASDPSPHRVT LITGDRVSVD
SKGRVVGLER AKGRTRIPVQ IRRIDGHTLV IPADAAGLVA DGTLDRRLFD VTELTRSRTG
ASGAKGPKVI VGYRGAATGA KADVRDAGTL RRTLKSLNAD AVQTTDRGAP GLWDALTDGD
RTASGVAHVW LDGVRRASLD KSVAQIGAPK AWAAGYDGKG VKIAVLDTGV DATHPDLEGQ
VVAAKNFSPA PGTTDKVGHG THVASIAAGT GAKSGGKYKG VAPGAAILNG KVLDDEGYGD
DSSILAGMEW AAEQGAQIVN MSLGGTDTPE VDPLEAAVDK LSAEKGVLFT IAAGNAGPES
VGSPGSADAA LTVGAVDDKD ALAPWSSTGP RAGDGAVKPD VTAPGVDITA ASAKGSVIAQ
EVGENPPGYV TIEGTSMATP HVAGAAAILK QQHPDWTYTE LKGALTASAK GGAYTPFQQG
AGRVQVDKAI KQNVIAEPVS VSFGTQQWPH TDDKPDARKL TYRNLGTKDV TLRLAVKATD
PEGHAAPAGF FKLGATEVTV PAGGTASVDF TVDTRLGGTL DGAYSAYVTA TGGGQSVRTA
AAVQREVESY DVTVKHIGRD GKPAPEYNTA LIGFSGLADE RFYQVPTTPS GTVRLRVPKG
TYLMDAWIAK DWVTMEGGLD WVVQPKLNVT RNTTLTIDAR TTRSADITVP DPRAEPVFAA
SGYFYDAAGI GIAAGLGSFA DLRMAHLGPE IASGLTQTWN AQYTRGAAAE YDVATSAKVK
KIQGHKVRHF TAGELAKVSS GLGAAAPGKT GALLPVGFLP DDVVFATPVE QKLPGTRTLY
VSTSDKIQWT FDMEQYSGRD ADGLLVVDAF YTLGDPQTFA AGKSYTKTFN TAVFGPHINK
DYGLFRDGND IYGFLPLFAD ANKHAGSSDV TSVTTNLYRN GSKIGTNADP LLGEAFKVPS
ADAEYRLTTS VKRSVKVAAA STRIDASWTF RSKKPSGDQV SLPASTVRFG AKTGLDSRAE
AGKKVTFPVT VVGAAAGRNL KSLHVYVSYD YGQTWKKLDV KNGKITVKNP AKGKGISFHG
KVADKKGNKA TISIYNAYYG K
//
