ID A0A0X3XLM8_9ACTN Unreviewed; 4507 AA.
AC A0A0X3XLM8;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:KUL71535.1};
GN ORFNames=ADL34_25100 {ECO:0000313|EMBL:KUL71535.1};
OS Streptomyces sp. NRRL WC-3605.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1609103 {ECO:0000313|EMBL:KUL71535.1, ECO:0000313|Proteomes:UP000052945};
RN [1] {ECO:0000313|EMBL:KUL71535.1, ECO:0000313|Proteomes:UP000052945}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL WC-3605 {ECO:0000313|EMBL:KUL71535.1,
RC ECO:0000313|Proteomes:UP000052945};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL71535.1}.
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DR EMBL; LLZN01000074; KUL71535.1; -; Genomic_DNA.
DR RefSeq; WP_062671797.1; NZ_LLZN01000074.1.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000052945; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0046483; P:heterocycle metabolic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd08955; KR_2_FAS_SDR_x; 1.
DR CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 2.
DR Gene3D; 3.30.70.3290; -; 2.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR Gene3D; 3.40.50.1110; SGNH hydrolase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010037; FkbH_domain.
DR InterPro; IPR000182; GNAT_dom.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR010033; HAD_SF_ppase_IIIC.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01686; FkbH; 1.
DR NCBIfam; TIGR01681; HAD-SF-IIIC; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 2.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 2.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 2.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF21089; PKS_DH_N; 2.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF14765; PS-DH; 2.
DR SMART; SM00827; PKS_AT; 2.
DR SMART; SM00826; PKS_DH; 2.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 2.
DR SMART; SM00823; PKS_PP; 3.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS51186; GNAT; 1.
DR PROSITE; PS00606; KS3_1; 2.
DR PROSITE; PS52004; KS3_2; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000052945};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 19..93
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 112..535
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1714..1789
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1808..2232
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3461..3537
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4352..4499
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS51186"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1079..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3176..3196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4507 AA; 475082 MW; D1F4E068CA4D3C56 CRC64;
MPAHASPKQF PDPPPRTPRD VRAWLESAVA RATGLDPDTV DPDRPLAELG LGSRQLVTLA
AELADLTGRT LDPSLVFDHP TIAALAEAVL DDRPAAPATP REPDGTAPHR HDDDIAIVSM
ACRLPGAEDP DALWRLLDEG REAVGDVPAG RWDTQDLYDP DPEATGRAYS LRGGYLRDID
RFDAAFFGIS PREAAAMDPQ QRLLLRTAWE AVERAGIVPA TLNGSSTGVY VGLYDSGYLA
SAGLGELDGH VGTGTAPSVA SGRIAYSLGL RGPAVTVDTA CSSSLVALHL AARALAGGEC
DLALAGGATL LLTPRGHVEF SRLRGLSPSG RCSPFSADAD GVVWAEGCGV VLLKRLADAR
RDGDRVLAVV KGSALNQDGR SQGLSAPSGP AQERVVRAAL DTAGLRPHDI DHVEAHGTGT
PLGDPIEGRA LAAVFGPDRP AGRPLGIGSL KSNIGHTQAA AGIAGVIKTV LALHHERIPA
SPHAGTPTRH IDWENGGLRV LDEARPWPRE AGRVRRAGVS AFGISGTNAH VVLEEAPEVP
APPPAASPGP VLLPLSARSL PALGAQAARL LGHLDARPEL PLPAVAATLA HHRTHFEHRA
VVRAADRDGL LRALHALAEG AADDDLVTGP PRTARTGKVA FVFPGQGSQW PGMARDLLDH
DPVFADELDR CDAALRPFTG WSVTSVLRGD PAAPGPDRVD VVQPVLFAVM VSLAAVWRAR
GVRPDAVVGH SQGEVAAACV AGALSLNDAA AVVALRSRAL TTLSGTGTMA VVALPHTEVE
RRTGDGAITV AAVNSGRSTV VSGAVDAVRA LVEGLEREQV FARVLDVDYA SHSDRVEPVR
DTVLDELDGV LTQPTAVTWY STVTAAPVTD ELEADHWYRN LREPVRFAPT VERMIADGHR
CFLELAPHPS LLTALNTIDE DLVTVGSLRR DEDGPACLDR AAARLHVHGH DVDWRRLVPP
TAPVDLPTYA WDEQRHWIEA ASRADAPGLF DRAAHPLLGI QLRSADETRW TFRNEWSAAT
ADWLADHTVH GRTVVSGTTL LELCRAALAV ARPDRPADVA GLLLLTPLTL PAHGTTEVSV
EVSTAGPTAE VTVHSRPRGP ESTDWTPHAT ASAAEPSEPP AGEPPTWPEE SAPAWDEDTY
ARLAALGLGY GPAFQGVREA TTTGAGTVLA RLSLPAAARD SADPYPVHPA LLDAALQVAA
VLEPLTGGRV LLPVAMARCV LSPGGATDLL AVVRRTPEPG EDVVLDVTLW DTDGFPAGRL
EGVRLRAAHR AEPTAGPEHG RHLYEVAWTP VGTAGPEPAE TPAGTVVRRW PAPEPGADPA
ATAHATAAAA LDELRALIAL PPDEAPARTV WVTTGAVAAT ATDTAAGYAR SVLWGLARAA
RAEHPDLGLT LVDVDTDARE LPLSAVVDTG EPEVALRGDR FLAPRLVRAR PAPPGAGPAI
PTDGTVLITG GLGAVGRRIA RLLAEHGVPR LLLTSGQGPG NPRSGEVTDE LTALGARVDI
AACDVADEAA LAAVLARVGD EAPLRGVVHC AGVLADGVLA ETTPERLAEV LRPKADGAAH
LHRLTANLDL GLFLLVSSAA GVVGTPGQAN YAAANTFLDQ LAHHRRACGL PALSLSYGAW
AGEGLAAEHA DLERMARLGH RALTPEQGAA LTALALRHDS AHLVAWSLDL PRLRAAAPAG
ALWRSLLPAR PAAPAGGPTL ADRLSRLPET ERAARVLALV REEAAQTLGL RSAEAVGPDQ
PLRDLGMDSV TAVDLRNRVG TRIGARLPAT LLFDHPTPAR LTDHLLTTVL GRPRPATAAR
PVHAPSAQEP VALVAMACRL PGGARDPEGL WRLLAEGRDA VGPFPDARWD VEALYDPDPD
APGKSYAREG GFLDDIDSFD AAFFGITPKE AAAMDPQQRL LLETAWESLE RAGIVPADLA
GSSTGVYVGM FGSDYLSGTR LDQLDGYVGT GSALSVASGR LAYTLGLNGP ALTVDTACSS
SLVAVHLAAQ ALRSGECDLA LAGGVTLMVT PGTFVEFSRL RGLSPTGRCR SFSDAADGAV
WAEGAGMLVL KRLGDARRDG DRVLAVLRGT AVNQDGRSQG LSAPNGPAQE RVIRRALAQS
GLRPADVDHV EAHGTGTTLG DPIEAGALAE VFGASRPEGR PLYVGSLKSN VGHTQAASGV
LGLIKVVQSL RHGTLPRTLH ADQPSRHVDW ADSGLRLLHE ETAWPASADR VRRAGVSAFG
ISGTNAHVIV EEAPPALAPT PEPSTGPRLF VLSGRGEDAL RGQAAALARH LADTGTDLHD
VAHTLARHRS HFEHRAVLVA DGRDELRTAL TDLAAGRLTP PRRREDTTGK VAFLYAGHGG
QWPGMALDLM TDSEEFAAEL TRIDGAVQRH AGWSVLTALR APEEFSPLER TEYLQPVLFA
VNAALTAAWR SVGVTPDAVA GHSLGEIAAA HSAGALSLDD AVAVVTGRAR AVVPLAGHGG
MLSLDVPRER AEELLAPYAG LLFVAAVNGP HATAVSGDAG ALADLRRSLD AQGVRARPLS
TPFASHTPLM APVRDDLLAR LTRVRGTPAA TPLYSTVLAE PVPGENLDAA YWYANLSEPV
RFADTVRRLL DDGHRYFVEL SPHPSLGAAV EAVAAETGVD AVTVGTLRRG AGRRDTLLRS
LGALHTAGHA PDWTALFPGD RRADLPTYAF ARERHWLAPA PATAPGASPL LGTHVEAGDE
PGRHLFQTEV DLHDSRFAYL TDHRVTGEVW LPGAAFLTMA LEAARTVQDG GDVRLTDVTF
LQPLRLDASR PVRLQLVLRP AVDGVRDFTV LAAPAGGPDA RWERHVTGRV TTASAAPGED
DPAALRARCD EPADVTALHA TLATLGIEYG PAFQGLESGR RSSTAAVARL TDRPAAGHLL
HPAVLDAAFH TAALPADASQ GRAFVPSGVG DLRHTGLRTT PAWATSVLRS VSGDTATLDL
RLYDEEDRLL LEAREFRLAA LSPLDGALFE TRWRPRPAAA EPPAPGTWLL LADTAGVAAD
LARRLDGSAP HVIARDGGEF AEEEPGRYVL DLADPDQLAR LLDEAFPHAP PRHVVQLTAL
DAPAIEDAPT AGEAARLGCL STLHLVRALA DRAWAPRLHI VVRGSQAAGD STHVTHPEQA
LAWGFGLAVA QEHPELRTTL VDLPPTGGAD DLWTQVRHAD DERLVALRPD GRRVPRLART
RPDDSGRPTP SGTHLITGGL GGLGRVVAER LAARGARRLA LLARSAPAES ALTWIDGLRE
RGVTVHVARA DVSDRPALAA ALDGVREALG PITGVVHAAG VLDDATLAHL GADRVEAVLA
PKVLGTALLT ELVPEAEEFV LFASAAGLLG SAGQSAYSAA NAFLDAWAHH LALRGRRALS
LDWGAWAGVG MVEGSDARAA QTARSGLLAL STGDGGELFE RVLTTSRRQL APLALDWELL
SLDPDAVRTR PILAELVTQP APATGTDELV EKVLAAADDA ERAVRLEAYV RARIAEVSGG
TAQVPATTAL KELGLDSLML VRLRNAFARD LGVELPAATV FSAADLRGLA EELRAALPGR
TATAPDEPAG TAQIPDEERL PATRDVVRLL RSARPGMPDA AHAVGLAVRL TTPVTRATLT
GVLDRLVARH AALRTAVTDA DGGGRVLRVR RDLTATPLRW TVVPDDTEPD AAARLRALLE
PPFDLATAPL WRFELLDGGE RGQILVYGAH HAVSDLQSLL LVAGEIDAEL TSGPLGDTVT
NREAHQLIEA QRADGSGGTD GWHETFRGSA RLDLTLSRPR PQTRTYRAGS VTLPIPDGLA
ERIAAAASTL AVTPAAFCLG VLTVLLGRRR ERERFVLAVP VDTRIHADAY DAVGFFGVPV
PFPAEARAGE RIEEVLRRTD GRLEKVLTKG AMFSDVLPVL AEEGLYRADA PLVEVYFNYV
RSGGGLKALE VLPAGTGYSD LDLMVTMTPD AGRIRLDHNL DILDAGAATG LGEELLLLLA
DTADDPSGPV RAPAPAARPG HRLALAATFA LGDLPRMCEA ALGAAAPGAP VTVAEAPYHQ
VAAALRDPSG VFADPDTTTG AVLLRAGDLE RFGPVDDDGL AELRTACTAA VRAAVERRRG
PLVVGVLPSA HAGERLARWE REVAADLTEV PGVAVLGPDA WTRDHGVDQP FDERTEQLAH
LPFTARFQAA VALRLAEAVR AAHRPAPKVI AVDGDETLWG GVAGEAGPEG VELGGSRALL
ARRLLQWRAA GALLALVSNN DEDTVRAVLD RPDSLLKAEH FSVISAAWEP KPDRLADAAR
ILGLGLDGFL FLDDNPAEIA RMRAAAPQVL SVTCPHVGEL PAFLDRLWPV VPVAATAEDA
LRARFYAQER QRDAVREETG FEEFLERLRL EVDVRALTDA DVGRAEQLVR RTNQFTLRAR
SADGGDVRRW RERGEVWTAS ARDRFGDYGQ IGLLALRAGD GRLDVTGWLL SCRALGRGVE
ERLLAWLAGR AEELGCAEVR LTAERTPRNT PARRLLAALG GGGLDDDLLE AVVTPDRLRE
FRSWRRA
//
