ID A0A0X3XMX1_9ACTN Unreviewed; 2340 AA.
AC A0A0X3XMX1;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:KUL72577.1};
GN ORFNames=ADL34_23030 {ECO:0000313|EMBL:KUL72577.1};
OS Streptomyces sp. NRRL WC-3605.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1609103 {ECO:0000313|EMBL:KUL72577.1, ECO:0000313|Proteomes:UP000052945};
RN [1] {ECO:0000313|EMBL:KUL72577.1, ECO:0000313|Proteomes:UP000052945}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL WC-3605 {ECO:0000313|EMBL:KUL72577.1,
RC ECO:0000313|Proteomes:UP000052945};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL72577.1}.
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DR EMBL; LLZN01000067; KUL72577.1; -; Genomic_DNA.
DR RefSeq; WP_062668908.1; NZ_LLZN01000067.1.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000052945; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd19540; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 4.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000052945}.
FT DOMAIN 959..1034
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2020..2094
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 937..961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2340 AA; 246600 MW; 7C743364463FA6A5 CRC64;
MNRPSAISEV LPLSPLQQGL LFLAEFDREG TDRYTLQLVV DLEDLTDAGA EALRGAAAAL
FDRHPQLRAC FRHRRSGEAV QIVPKAVELP WREVDLADAD DAELDRLARE DRLRRFDLGR
PPLHRFTLLR APGGRARLLW TVHHILVDGW SMATLTRELA RYAAGPGEPA PVPPYRAHLS
WLGTRDREAA RAAWAEALAG VSEPTRLVVD DGTADARDLP ERIPVELAPD VAARLTGFAR
ARGLTVNAVV QGCWALLLSR LTGQDTVLFG AVTSGRPAEL PGVEDMVGLF ANTLPVRVDV
DPRLTPAELF AAVQERQAAL LPHEHLTLAE VQQLTAVRGE LFDTALLFQN YPMDRSPLTP
SEPGSGPRVT GVDIHSATHY PLTLTVFPGT PFGLAVDHLP SRVPAAAARA LGLRLARLLE
AAVTRPDEPS GRLDMLLDDR EYALVLTGRN RTRTDLPGRL PAPLLERWAG RTPDAPAVHC
GTERLTYGEL LARADGLAAA LRAAGAGPER VVALALDRSC DLVVAVLAVL RTGAAYLPLD
PDYPADRLRH MLADAAPVVT LTHRRVAPLL ADVSAGTTWV LDGEGVPEGT PADGGGPVTD
PRCPAYVIYT SGSTGRPKGV VVPHEALANL VHDMAGRLEV VPGDRFLAVT TFGFDIANLE
LLVPLAAGAE LVLADRETVR DPAALADAIT STGATLMQAT PSLWQTLTAR HAPALRNLRA
LVGGEALPEP LARALVTHCA SVSNVYGPTE TTVWSTAAPL APALQGPPPI GEPISNTAVY
VLDPALRPAP DGSFGELYIG GTGLARGYLG RPALTADRFV ADPYGPPGSR MYRTGDIVRR
SADGTALEYA GRSDHQVKIR GHRVELGEIE SVLGALPGVE RAVVTARPGH GGEARLVAYV
VPAGTDRDRL RERASAVLPT HMVPAVYVPL DTLPATPNGK VDRKALPDPP EDRGGSGRPP
ATAREELLCA AFAEALGVER VGADDDFFAL GGHSLSAVRV ANRLRAELGV DVPVRTLFDT
RTAEALARAL PGAPRTPGRP ALLPAPPEDR AAAPLSYAQE RLWFLSRMGV PAGTYNIPLA
VRFTGPLDPA VLGRALADVV ARHACLRTVF VESDGLPSQL VLSAREVAGA GAALEVVGLP
GEEALAGALA EEAGHAFDLS ARVPLRARLF TLDAGSHVLA LTLHHIAADG WSLEPLARDL
ASAYRARLDG RAPDWAPLPV RYTDYARWQR ELLGTRDDPD SLASGELAHW KRVLEGLPEE
LELPADFPRP ARASGRGGSV ARSVPAEAHA RLAGLARRSG ASLFMAVQAG LAALLTRLGA
GTDIPLGSPV AGRADDALRD LVGCFVNTLV LRTDTSGDPT FTGLLERVRE TDLTAYAHAE
LPFEHLVDAL KPTRSLARQP LVQVVLAFRN AADPLQAIGG IAAAVEMVPS ATAKFDLSFE
VTERAMPDGT PDGLEILLEY NADLFTEATA DRIARALATL LDAASRTPDA PVGTLALLTA
EERDALLTLH QGRVRPRPPV TLTDLFEAHA AKAPDRPALV VPGAAPVTYG ELDAEAGRLA
RRLLGRGVGP GDVVALALPR SPDTVVALLA VLKTGAAYLP VDPDYPAERI AYMLRDARPA
EVLSVRAVAG RLPGVSPLLL DDPAGRDERA AAPPAVRRAG PRDTAYVIYT SGSTGRPKGV
GVPHAGAANL AATLREGLGA GPGTRVLQFA SFSFDATVWE LAASLFSGGT LVFATAESRL
SPPLLAGLIA ENAVNHAILP PSVVAGFPDP AALPRDLCLL VGGEACPPSL VERVAPHVTL
RNAYGPTETS VCATWSDPLT PGGRPPIGRP LDNVRLYVLD AALAPAPVGV TGELCVAGAG
LAHGYLGRPG ITAARFVADP YGPPGTRMYR TGDLVRVLPD GSLDYVGRAD QQIKLRGFRI
EPGEIEAALT RHPVVAQAAV VATPTPAGGK QLTGYVVPVA GVAGVDAAAV LGHAAGFLPA
HMVPAALVTL PRLPLTTNGK LDVRALPAPG APASGRPSRP PRTAAEQALA DVFREVLGLA
EVDADGDFFA LGGDSLRSVR IVSRAAKAGL TLSLSDVFTH RTVAALAAAS ERRAPVEEGD
DEGFTALLPV RPSGSLAPLF CVHGGVGFGL PFAGLAPHLV PERPVFALQS DGVAAPAGAW
SPPADVPSLA ALYVERIRGV QPHGPYHLLG WSFGGLVAHE MAVRLQADGE EVAFLAALDV
CPVAPEDPVV SDERMRTAFL EHHAAGRAVD EAELERLMTV MRHHTGIARH FTPGRFDGPL
TLFVAADEQD APVADPAARW EPYVDGPVVV HEVGCGHEEM LSGEPARLIG TLTERALRRT
//
