ID   A0A0X7BF54_9FLAO        Unreviewed;       905 AA.
AC   A0A0X7BF54;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=DNA gyrase subunit A {ECO:0000313|EMBL:KVV16063.1};
DE            EC=5.99.1.3 {ECO:0000313|EMBL:KVV16063.1};
GN   Name=gyrA_1 {ECO:0000313|EMBL:KVV16063.1};
GN   ORFNames=AP058_00364 {ECO:0000313|EMBL:KVV16063.1};
OS   Flavobacterium sp. TAB 87.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=1729581 {ECO:0000313|EMBL:KVV16063.1, ECO:0000313|Proteomes:UP000059935};
RN   [1] {ECO:0000313|EMBL:KVV16063.1, ECO:0000313|Proteomes:UP000059935}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TAB87 {ECO:0000313|EMBL:KVV16063.1,
RC   ECO:0000313|Proteomes:UP000059935};
RA   Gilbert D.G.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. {ECO:0000256|ARBA:ARBA00008263}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KVV16063.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LLWK01000027; KVV16063.1; -; Genomic_DNA.
DR   RefSeq; WP_066306170.1; NZ_LLWK01000027.1.
DR   AlphaFoldDB; A0A0X7BF54; -.
DR   STRING; 1729581.AP058_00364; -.
DR   PATRIC; fig|1729581.3.peg.390; -.
DR   OrthoDB; 9806486at2; -.
DR   Proteomes; UP000059935; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   Gene3D; 3.30.1360.40; -; 1.
DR   Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR   Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR   InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a_sf.
DR   InterPro; IPR002205; Topo_IIA_dom_A.
DR   PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:KVV16063.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000059935};
KW   Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT   DOMAIN          60..494
FT                   /note="DNA topoisomerase type IIA"
FT                   /evidence="ECO:0000259|SMART:SM00434"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          466..493
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   905 AA;  103012 MW;  09A8AC2C36B79648 CRC64;
     MKDEEDDNSI PNNEENNSEE NSIDENQEEI HEEEIIEVEA KHFEGGHFYE NNNEDGDTIT
     KVTGMYKDWF LDYASYVILE RAVPAIEDGF KPVQRRIMHS LKELDDGRYN KVANVVGHTM
     QYHPHGDQSI GDAMVQIGQK DLLIDCQGNW GNILTGDGAA ASRYIEARLS KFALEVLYSP
     KITDWGVSYD GRRAEPNNLP VKFPLLLAQG AEGIAVGLSM KVLPHNFNEL IDASIKILKG
     KAFTIYPDFV TQGIADISNY NDGLRGGRVR VRAKISQLDK NTLVITQIPF STNTTTLIDS
     ILKANDKGKI KIKKIEDNTA ADVEILIHLF PGVSPDKTID ALFAFTACET SIAPLGCIIE
     DNKPLFIGVS EMLKISTERT SDLLRQELEI QLEELKNKWH FSTLEKIFIR EEMYIDFKLY
     GDRESLYNYL YDRFEVFKAS FVREINDEDL NRLTQIPMIR ITRFDSDKAD DVIARLEDEM
     KEVEHHLANL IDFAIAYFSK LKEKYGKGRE RQTELRIFDD IEATKVVLRN TKLYVNREEG
     FVGTSLKKDE YLTDCSDIDD VIVFLRDGKM MITKVDAKTF VGKDIIHIAI FDKSDKRTIY
     NMLYRDGKSG PSYLKRFNVS GVTRDKLYDL TNGSTGSQVV YFSHNPNGEA EVITIILRQV
     GSIKKLKFDV DFANLAIKGR ASKGNLATKY PIKKIELKEK GISTLLPRKV WFDDTVKRLN
     VDGRGELLGE FKPNDKILII SQAGKVKVII PELSTHFEED MIILEKWIPK KPISAIYYEG
     EKARYYVKRF LVENEGKEES FITEHPNSQL EIVSTDYRPV AEIVFAKVKG VQKDNLNVEI
     EEFIAVKGFK ALGNQLTADK LKQVNLLEPL PYDEPEEEIE ESIAIPDSDV ETQLEDDGQI
     GLVLD
//