ID A0A0X8HR57_9SACH Unreviewed; 411 AA.
AC A0A0X8HR57;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Autophagy-related protein 17 {ECO:0000256|ARBA:ARBA00013806, ECO:0000256|RuleBase:RU368080};
GN ORFNames=AW171_hschr31760 {ECO:0000313|EMBL:AMD19898.1};
OS Eremothecium sinecaudum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=45286 {ECO:0000313|EMBL:AMD19898.1, ECO:0000313|Proteomes:UP000243052};
RN [1] {ECO:0000313|EMBL:AMD19898.1, ECO:0000313|Proteomes:UP000243052}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58844 {ECO:0000313|EMBL:AMD19898.1,
RC ECO:0000313|Proteomes:UP000243052};
RA Dietrich F.S.;
RT "Genome sequence of the yeast Holleya sinecauda.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Autophagy-specific protein that functions in response to
CC autophagy-inducing signals as a scaffold to recruit other ATG proteins
CC to organize preautophagosomal structure (PAS) formation. Modulates the
CC timing and magnitude of the autophagy response, such as the size of the
CC sequestering vesicles. Plays particularly a role in pexophagy and
CC nucleophagy. {ECO:0000256|RuleBase:RU368080}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU368080}.
CC Preautophagosomal structure membrane {ECO:0000256|RuleBase:RU368080};
CC Peripheral membrane protein {ECO:0000256|RuleBase:RU368080}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the ATG17 family.
CC {ECO:0000256|ARBA:ARBA00006259, ECO:0000256|RuleBase:RU368080}.
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DR EMBL; CP014243; AMD19898.1; -; Genomic_DNA.
DR RefSeq; XP_017986894.1; XM_018131218.1.
DR AlphaFoldDB; A0A0X8HR57; -.
DR STRING; 45286.A0A0X8HR57; -.
DR GeneID; 28723124; -.
DR OrthoDB; 1940609at2759; -.
DR Proteomes; UP000243052; Chromosome iii.
DR GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR InterPro; IPR007240; Atg17.
DR InterPro; IPR045326; ATG17-like_dom.
DR PANTHER; PTHR28005; AUTOPHAGY-RELATED PROTEIN 17; 1.
DR PANTHER; PTHR28005:SF1; AUTOPHAGY-RELATED PROTEIN 17; 1.
DR Pfam; PF04108; ATG17_like; 1.
PE 3: Inferred from homology;
KW Autophagy {ECO:0000256|RuleBase:RU368080};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU368080}.
FT DOMAIN 17..386
FT /note="Autophagy protein ATG17-like"
FT /evidence="ECO:0000259|Pfam:PF04108"
FT COILED 79..106
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 350..377
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 411 AA; 47893 MW; 70215E820C90E45A CRC64;
MSEDESITLY WDNAQRTLSK AQLMCQKSQN MIADLQSTVT AWQKTISKIQ FTICCIDNQT
IYLAKSILEG MIGKRLLEKE WERNVLDNLS KEMKRLKEEI LAKMEILRDT KHVLGDSDET
LADFISMGNL NILNEKFRDL DVINTQVINI RSQHDLLLKK VLNQLLKNKI RKLKHECETY
FGSEGVKFIS EKSYGEIIVL EEELVELLRS LTDHYDKCKL LKSGTLPSAE YAELLRVVAN
DNDELDKIMG ILNDAVDDIS RLAEGIYATI QQKEKEKQHM KSSMLKVANE LKKYEDYLLV
FQGIEELISK FKQTCIQDIA KVQELSSFYD NFLSSYKHLL EEVERRSNVA KQMKRIIERC
EEELKALTDE DLKARQMFLL EHGDYLPENI WPGHIDDLEP LYKLSHEIKE I
//
