ID   A0A0X8HRL6_9SACH        Unreviewed;       951 AA.
AC   A0A0X8HRL6;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=AW171_hschr32034 {ECO:0000313|EMBL:AMD20157.1};
OS   Eremothecium sinecaudum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=45286 {ECO:0000313|EMBL:AMD20157.1, ECO:0000313|Proteomes:UP000243052};
RN   [1] {ECO:0000313|EMBL:AMD20157.1, ECO:0000313|Proteomes:UP000243052}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58844 {ECO:0000313|EMBL:AMD20157.1,
RC   ECO:0000313|Proteomes:UP000243052};
RA   Dietrich F.S.;
RT   "Genome sequence of the yeast Holleya sinecauda.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-
CC         (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP +
CC         diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003,
CC         ECO:0000256|RuleBase:RU000617};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|ARBA:ARBA00007572, ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; CP014243; AMD20157.1; -; Genomic_DNA.
DR   RefSeq; XP_017987153.1; XM_018131664.1.
DR   AlphaFoldDB; A0A0X8HRL6; -.
DR   STRING; 45286.A0A0X8HRL6; -.
DR   GeneID; 28723393; -.
DR   OrthoDB; 8251at2759; -.
DR   Proteomes; UP000243052; Chromosome iii.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd07903; Adenylation_DNA_ligase_IV; 1.
DR   CDD; cd07968; OBF_DNA_ligase_IV; 1.
DR   Gene3D; 3.40.50.10190; BRCT domain; 2.
DR   Gene3D; 1.10.3260.10; DNA ligase, ATP-dependent, N-terminal domain; 1.
DR   Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR044125; Adenylation_DNA_ligase_IV.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   NCBIfam; TIGR00574; dnl1; 1.
DR   PANTHER; PTHR45997; DNA LIGASE 4; 1.
DR   PANTHER; PTHR45997:SF1; DNA LIGASE 4; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SUPFAM; SSF52113; BRCT domain; 1.
DR   SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000617};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172,
KW   ECO:0000256|RuleBase:RU000617}; DNA repair {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU000617}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          381..500
FT                   /note="ATP-dependent DNA ligase family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50160"
FT   DOMAIN          688..786
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
FT   DOMAIN          849..950
FT                   /note="BRCT"
FT                   /evidence="ECO:0000259|PROSITE:PS50172"
SQ   SEQUENCE   951 AA;  109726 MW;  667F1A6D0F159C93 CRC64;
     MEKEEEESSP ELILEAESKP VNFSPSPDFV WLCNELFVKL EDASIKKNEL GKPRRLRLLE
     IISHFYRLWR TTVGNDIYPA LILALPYLDK RTFRLKEATL VQAICRYLKL PRNSETEKRL
     IYWKKNAPRG SKLSKSCVEE IQKRKKEYLG PSRLSIDKVN ECLDQLHHDS NVGKWGYIGL
     SKSKTFRYCM EHMSFTEMRY FFDIILKVSV VGGLEGLLLR CWHPDAETYF KVVSDLRVVT
     ETLWNQSKRL EKNDLTVRIG YPFSPQLALR LKKSDEDLAR GYKNDFMIEE KMDGERIQLH
     YKDYGHTISY WSRNGINYTY LYGENQNLGS ISNCLQFVDG VKNCILDGEM VTYNRETNMI
     LPFGLTKTSA GNQLTYEATG EYESSYRPLY MVFDLIYLNG KPLTALELWK RKEYLQKILV
     PTENVVEILP FSRCSEASSI SASLGAAISR GSEGIILKDS HSKYLLGRRS DCWIKIKPEY
     LENFGENLDL VIIGRIRGKK DSFICALAIV EDINANDDSL KIADMETTPE PHIVEPNIRK
     FISFCSIANG ISNEEFKQIE RLTRGNWISY SENPPSTDWV EFGTKTPNEW IDPKHSIVLE
     VKARSIDNEE VGKERYKTGS TLHGAYCRCI RYDKDWKTAC TLEEFKQARE AKEYYNHHYG
     NSVVKSKKSP SKKREFHVVG TVEDSKVTGK RFLHGCHFYV LSGYFDKRFG IRVDNTMVAE
     NIVAHGGTYV HNLNIRAGLG KLYILGGKLT RECKILIDRG YDIIHPSWLM DSVMYGTMLR
     IEPRYIYNVG IEFMANVSAR VDEYNDSYQI PIECSEYEHI IGESKELLLS EESPALNTNT
     VNEELPFLLF QRMNIFILAD DVHYQDRVDL IKWKIRAYQG ALTDDIANAN LIVAIEYNYS
     KAGIEQVRHT VASLIGENIP GRPIPKITVD RWIEACIEEQ CLVDEEDYLA V
//