ID   A0A100I7P2_ASPNG        Unreviewed;       283 AA.
AC   A0A100I7P2;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Formyltetrahydrofolate deformylase {ECO:0000313|EMBL:GAQ36208.1};
GN   ORFNames=ABL_01547 {ECO:0000313|EMBL:GAQ36208.1};
OS   Aspergillus niger.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=5061 {ECO:0000313|EMBL:GAQ36208.1, ECO:0000313|Proteomes:UP000068243};
RN   [1] {ECO:0000313|Proteomes:UP000068243}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An76 {ECO:0000313|Proteomes:UP000068243};
RX   PubMed=26893421; DOI=10.1128/genomeA.01700-15;
RA   Gong W., Cheng Z., Zhang H., Liu L., Gao P., Wang L.;
RT   "Draft genome sequence of Aspergillus niger strain An76.";
RL   Genome Announc. 4:E0170015-E0170015(2016).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAQ36208.1}.
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DR   EMBL; BCMY01000002; GAQ36208.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A100I7P2; -.
DR   PaxDb; 5061-CADANGAP00001126; -.
DR   VEuPathDB; FungiDB:An01g11650; -.
DR   VEuPathDB; FungiDB:ASPNIDRAFT2_1182424; -.
DR   VEuPathDB; FungiDB:ATCC64974_14100; -.
DR   VEuPathDB; FungiDB:M747DRAFT_298414; -.
DR   OMA; QILNIHH; -.
DR   Proteomes; UP000068243; Unassembled WGS sequence.
DR   GO; GO:0008864; F:formyltetrahydrofolate deformylase activity; IEA:InterPro.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:UniProt.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd04875; ACT_F4HF-DF; 1.
DR   CDD; cd08648; FMT_core_Formyl-FH4-Hydrolase_C; 1.
DR   Gene3D; 3.30.70.260; -; 1.
DR   Gene3D; 3.40.50.170; Formyl transferase, N-terminal domain; 1.
DR   HAMAP; MF_01927; PurU; 1.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR041729; Formyl-FH4-Hydrolase_C.
DR   InterPro; IPR002376; Formyl_transf_N.
DR   InterPro; IPR036477; Formyl_transf_N_sf.
DR   InterPro; IPR004810; PurU.
DR   InterPro; IPR044074; PurU_ACT.
DR   NCBIfam; TIGR00655; PurU; 1.
DR   PANTHER; PTHR42706; FORMYLTETRAHYDROFOLATE DEFORMYLASE; 1.
DR   PANTHER; PTHR42706:SF1; FORMYLTETRAHYDROFOLATE DEFORMYLASE 1, MITOCHONDRIAL; 1.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00551; Formyl_trans_N; 1.
DR   PIRSF; PIRSF036480; FormyFH4_hydr; 1.
DR   PRINTS; PR01575; FFH4HYDRLASE.
DR   SUPFAM; SSF55021; ACT-like; 1.
DR   SUPFAM; SSF53328; Formyltransferase; 1.
DR   PROSITE; PS51671; ACT; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563}.
FT   DOMAIN          4..86
FT                   /note="ACT"
FT                   /evidence="ECO:0000259|PROSITE:PS51671"
SQ   SEQUENCE   283 AA;  31379 MW;  379E812608442BFE CRC64;
     MSYILTLSCP DRPGIVHAVT AYLVQQNLNI IDSSQYGDPT SQRFFMRVHF KDESSPAKSL
     DDLRAAFQPT AESLTMTFQL VPASSKPRVL IMVSKIGHCL NDLLFRASTG QLPIEIPLIV
     SNHPDFATLA ATYNIPFLHL PVTADTKPQQ EGRILELIRE HNIDLVVLAR YMQVLSPTLC
     EAMSGKIINI HHSFLPSFKG AKPYHQAFDR GVKIVGATAH FVTSDLDEGP IIEQNVVRVN
     HAMSPKELTH AGSNVESNVL ATAVKYFAER RVLLNGHKTV VFN
//