ID A0A100I9T5_ASPNG Unreviewed; 1155 AA.
AC A0A100I9T5;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Ras guanine-nucleotide exchange protein {ECO:0000313|EMBL:GAQ37322.1};
GN ORFNames=ABL_02065 {ECO:0000313|EMBL:GAQ37322.1};
OS Aspergillus niger.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=5061 {ECO:0000313|EMBL:GAQ37322.1, ECO:0000313|Proteomes:UP000068243};
RN [1] {ECO:0000313|Proteomes:UP000068243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An76 {ECO:0000313|Proteomes:UP000068243};
RX PubMed=26893421; DOI=10.1128/genomeA.01700-15;
RA Gong W., Cheng Z., Zhang H., Liu L., Gao P., Wang L.;
RT "Draft genome sequence of Aspergillus niger strain An76.";
RL Genome Announc. 4:E0170015-E0170015(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAQ37322.1}.
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DR EMBL; BCMY01000003; GAQ37322.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A100I9T5; -.
DR PaxDb; 5061-CADANGAP00003708; -.
DR VEuPathDB; FungiDB:An04g00880; -.
DR VEuPathDB; FungiDB:ASPNIDRAFT2_1221154; -.
DR VEuPathDB; FungiDB:ATCC64974_77040; -.
DR VEuPathDB; FungiDB:M747DRAFT_29491; -.
DR OMA; EEVWERD; -.
DR Proteomes; UP000068243; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 60..126
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 690..810
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 870..1113
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 263..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 608..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1155 AA; 128892 MW; 539B580119C5616A CRC64;
MESMKRHIAP LKIEKGNLNY NYDDQQHHYH YQHNLEMSPP LTPYENKDDS MEQSETPRAV
FHNYLRAFYP YHPSGNVSPS TVTLPLDQGD IVLVHSVHTN GWADGTLLDT GARGWLPTNY
CEAYDQQPMR PLLKALTDFW DIIRGGCGFP LNDAGNQDLV RGLIAGQKSE CLTRDCILVT
SHDGLRRNRK ALLAELSSLV RTTKRFQEVA SSNATQDEMD YMVDEMLLKA FRIVTRGVRF
LDVWTEEVGL SRTIAELEQQ SGYQQGPLTT VSETRPISEA AGSEADTERN ESRLMNRSRL
DMSRASTRLD DSQQTRPVSV TTKRISVSHR VSTSGPAAIA RNPNLASERL NDAYDAFLGV
LGSFIGLHLQ SRSSTELVVT TEQAVRSCRA LLTVVEATCE HDPQGSGLLE QARDTMYERL
SELVYAARDA FRPAHSPDDE LVFLPDEGKR LVDAATDCVR AAGSCLAKAR LMLEQCGDFE
LEAMPQDLPA ATGAMTDANK TPQPPKTSTF AGHQNRSQEA SLRLPPPPLQ IPNSINNRYS
PPTPGLTDDT TPSSFQSRNG ASTPGTDMSS FPSTSHLSTS LDKLSFSSHD TQPIEIPPHR
DSQAKSDVSE SFGRGITSNG SSFTFNSRLR DSEMSGVSQT STRATSPDIG NHYQVPSLKG
SISHSTLAEE TEEGEANILE KTYAHELIFK DGQIMGGSLR ALVEKLTAHQ STPDAMFVST
FYLTFRLFAT PIEFAETLVD RFNYIGDTPH TAGPVRLRVY NVFKGWLESH WRHDCDNCAL
EYIVNFASTT LMHNLPSAGK RLVELAEKVS MVHGPVVPRL VSSMGKTNTA TAQYVHPDTP
LPPPILGKKE VNLLKHWKNG EGTITILDFD PMELARQFTI KESRIFCAIL PEELLATEWM
KKSGSLAVNV RAMATLSTDL THLVADSILQ LEEPKKRAAI IKHWVKIANK CLELSNYDSL
MAIICSLNSS MISRLKRTWE VVSQKTKTTL EYLRGIVDVS RNYYVLRQRL QNRVPPCLPF
VGTYLTDLTF VDHGNQALRT LPTDEGDMAV INFDKHMKTA KIISELQRFQ IPYRLTEVPE
LQAWMQNELV RVRSSGEKSL QTFYRRSLVL EPREVPQARM QPESSSSSIL ENAKDKFDFL
SWTHPSKSKS VATNG
//