ID A0A100IC10_ASPNG Unreviewed; 1072 AA.
AC A0A100IC10;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Choline monooxygenase, chloroplastic {ECO:0000256|ARBA:ARBA00014931};
DE EC=1.14.15.7 {ECO:0000256|ARBA:ARBA00012763};
GN ORFNames=ABL_02694 {ECO:0000313|EMBL:GAQ38505.1};
OS Aspergillus niger.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=5061 {ECO:0000313|EMBL:GAQ38505.1, ECO:0000313|Proteomes:UP000068243};
RN [1] {ECO:0000313|Proteomes:UP000068243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An76 {ECO:0000313|Proteomes:UP000068243};
RX PubMed=26893421; DOI=10.1128/genomeA.01700-15;
RA Gong W., Cheng Z., Zhang H., Liu L., Gao P., Wang L.;
RT "Draft genome sequence of Aspergillus niger strain An76.";
RL Genome Announc. 4:E0170015-E0170015(2016).
CC -!- FUNCTION: Catalyzes the first step of the osmoprotectant glycine
CC betaine synthesis. {ECO:0000256|ARBA:ARBA00002149}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] =
CC betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin];
CC Xref=Rhea:RHEA:17769, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15379, ChEBI:CHEBI:15870, ChEBI:CHEBI:33737,
CC ChEBI:CHEBI:33738; EC=1.14.15.7;
CC Evidence={ECO:0000256|ARBA:ARBA00001883};
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|ARBA:ARBA00001962};
CC -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC choline pathway; betaine aldehyde from choline (monooxygenase route):
CC step 1/1. {ECO:0000256|ARBA:ARBA00004866}.
CC -!- SIMILARITY: Belongs to the choline monooxygenase family.
CC {ECO:0000256|ARBA:ARBA00010848}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAQ38505.1}.
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DR EMBL; BCMY01000003; GAQ38505.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A100IC10; -.
DR PaxDb; 5061-CADANGAP00004593; -.
DR VEuPathDB; FungiDB:An04g09790; -.
DR VEuPathDB; FungiDB:An04g09810; -.
DR VEuPathDB; FungiDB:ASPNIDRAFT2_1222968; -.
DR VEuPathDB; FungiDB:ASPNIDRAFT2_130535; -.
DR VEuPathDB; FungiDB:ATCC64974_86550; -.
DR VEuPathDB; FungiDB:ATCC64974_86560; -.
DR VEuPathDB; FungiDB:M747DRAFT_140870; -.
DR VEuPathDB; FungiDB:M747DRAFT_313653; -.
DR OMA; WRKKTRC; -.
DR UniPathway; UPA00529; UER00430.
DR Proteomes; UP000068243; Unassembled WGS sequence.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0019133; F:choline monooxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniPathway.
DR CDD; cd12148; fungal_TF_MHR; 1.
DR CDD; cd00680; RHO_alpha_C; 1.
DR CDD; cd03469; Rieske_RO_Alpha_N; 1.
DR Gene3D; 2.102.10.10; Rieske [2Fe-2S] iron-sulphur domain; 1.
DR InterPro; IPR017941; Rieske_2Fe-2S.
DR InterPro; IPR036922; Rieske_2Fe-2S_sf.
DR InterPro; IPR015879; Ring_hydroxy_dOase_asu_C_dom.
DR InterPro; IPR001663; Rng_hydr_dOase-A.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR PANTHER; PTHR43756; CHOLINE MONOOXYGENASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR43756:SF5; CHOLINE MONOOXYGENASE, CHLOROPLASTIC; 1.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00355; Rieske; 1.
DR Pfam; PF00848; Ring_hydroxyl_A; 2.
DR PRINTS; PR00090; RNGDIOXGNASE.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR SUPFAM; SSF50022; ISP domain; 1.
DR PROSITE; PS51296; RIESKE; 1.
PE 3: Inferred from homology;
KW 2Fe-2S {ECO:0000256|ARBA:ARBA00022714};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 49..136
FT /note="Rieske"
FT /evidence="ECO:0000259|PROSITE:PS51296"
FT REGION 467..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1072 AA; 121031 MW; 8457EE4C0221B7D0 CRC64;
MASALWNYLG LRETPTAPTN EAVRALPASW YTSQEMFELE RRAIFSRKWL LTTHKLRLPN
TGDWLQYEVS GFNFVLVRDK EGNINAFHNV CRHRAFPLVT EEKGSARIFA CKYHGWSYGL
NGKLAKAPGY QDLDGFDKSK NSLLPIHVHL DANGFIWVNL DAGEQPEISW DDDFKGIDLQ
SRFADVKWED YTFDHTWEQE GDYNWKILAD NYNECYHCAT THPDIPALAD LATYSVDTKD
GGIIHDAHSK PDQIAAGLRI ASTYYFPNAS MTVSPHFFFM QRFVPLSPTR SVMKYEVYRN
KNSSDEDFEL INTMYKRIMS EDKYLCDLTQ KNLNAGVFVN GELHPKMEKG PLYFQKVVRD
VVTEHFQREE KEGQEYWPAR QRVPKEAATS AQDMQFCANL GCGAGKECCS NIGAQPPAAV
AWQSFRGCSR PFLDFAVADA PPQKDRLAEL EEKVNLILNG NILARSTGPE TKLSPPSPRR
RDSHTPYPVP SGLGEGTTPH SSPSVIARAI NLYVEHCHRQ PVWCFDFDGP GEPGSLPEEL
ICSLLALTLR YLHEQEQGQH YADDARTLIM LRIANGTVEL ATIESLCLLS YSSFIDGNTH
LGQFYLGLAS QLCRAAMLDV AVAYSTDDPH MERKKRLFWS LQLLEQSYGR QTGILRTSTE
IWRPPYFATD GDQDSHKATG PPPPPMPQDS VGCTNPHDTG IWNMSNQFGW VWSNVRGYVS
DCARSKMKEP WRHESMYSMI LSDLTEVENR TPFCHRYDHV QFYERTGEEL SYELAYWVPW
LKLQFMYHAI LTVLNHPFLY IMASRQNPNL AIPNSFWRRS SELVVLHATW IVRLIDMVVE
KEVRLSDPFF AHVAAIAATV QLYYCCAGDP RLKYKSRVDY AKCREFLRTF ATTSRACEGL
HRILDQMMRI ASGSENVDYE TWLPSKIYLS IPLMWDILQF NVTDRSAGGR ADGRLLHSSL
AASAVGQGSE EDSTLEVIVT TSPEVTVNTA DGGQAVPLPL YRTPATSKAN AAATSITRDT
LVAPIDSLMV NTPWLWADSA PLGDMESSLG YANSGPGGGD AEFSSWWNLG NL
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