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Database: UniProt
Entry: A0A100IFH0_ASPNG
LinkDB: A0A100IFH0_ASPNG
Original site: A0A100IFH0_ASPNG 
ID   A0A100IFH0_ASPNG        Unreviewed;      1105 AA.
AC   A0A100IFH0;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   05-JUN-2019, entry version 17.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=ABL_03514 {ECO:0000313|EMBL:GAQ40249.1};
OS   Aspergillus niger.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=5061 {ECO:0000313|EMBL:GAQ40249.1, ECO:0000313|Proteomes:UP000068243};
RN   [1] {ECO:0000313|Proteomes:UP000068243}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=An76 {ECO:0000313|Proteomes:UP000068243};
RX   PubMed=26893421; DOI=10.1128/genomeA.01700-15;
RA   Gong W., Cheng Z., Zhang H., Liu L., Gao P., Wang L.;
RT   "Draft genome sequence of Aspergillus niger strain An76.";
RL   Genome Announc. 4:E0170015-E0170015(2016).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:GAQ40249.1}.
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DR   EMBL; BCMY01000005; GAQ40249.1; -; Genomic_DNA.
DR   EnsemblFungi; GAQ40249; GAQ40249; ABL_03514.
DR   Proteomes; UP000068243; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000068243};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000068243};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      130    475       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      539    969       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1007   1081       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     63       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A100IFH0}.
FT   REGION       76     98       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A100IFH0}.
FT   COILED     1081   1105       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1105 AA;  124809 MW;  FB79A103D97DE890 CRC64;
     MPEAVAMPQK RVLGDASNNP RGVATDPSAL KKRRIENGPA AAMKPPTNGQ RRVPGSSQPQ
     KSQFEAEVLE KLTQDINGLK DSNSEKDQQW ERPPLGEFDP STENICFQQI DAEEGTIMGG
     KTAVRLFGVT EAGQSVLLHV TGFQHYLYIA APVNFTKDDC EPYRAFLESR VGQFQPTIQS
     VQITMRENIY GFQGNQKSYY LKITVTDPKF ISKVRSALEQ GGAQSLNYKG LWNNSDGGIL
     TFDSIQYLLR FMIDTDISGM SWVEAKAGKY RLFQQHEKVS NCQIEASVDY RDLISHPPNG
     EWAKMAPLRI LSFDIECAGR KGIFPEPNQD PVIQIANVVT RYGESKPFIR NVFVLDTCSL
     IVNTQILEFK DEAKMLMAWR EFVQKVDPDV IIGYNIANFD FPYLLDRAKH LKCTGFPYWT
     RLNGVQSQSK ETNFSSKQMG NRDTKSTNTN GRIQLDMLQL VQRDYHLRSY TLNSVSYEFL
     GEQKEDVHHT MITELYNGTP DSRRRLAVYC LKDAYLPQRL MDKLMCLVNY TEMARVTGVP
     FNFLLSRGQQ VKFISQLFRK ALEQQLVIPN TKSNDEQDYE GATVIEPVRG YYGVPIATLD
     FASLYPSIIQ AHNLCYTTLL NKNSVERLKL VKDEDYIVTP NGDMFCTAKV RKGLLSQILE
     ELLSARKRAK KELATETDPF KKAVLNGRQL ALKISANSVY GLTGATVGKL PCLPIASSTT
     SYGRQMIEKT KQEVEARYTI ANGYSHDAKV IYGDTDSVMV KFGVDNLEEA MKLGQEASEY
     VSSKFLKPIK LEFEKVYFPY LLINKKRYAG LYWTNPNKYD KMDTKGIETV RRDNCLLVQN
     VIETVLQKIL VERDIDGAQD YVKDTISDLL QNKIDMSKLV ITKALSKDAY TAKQAHVELA
     ERMRKRDAGS APTLGDRVAY VIIKGAGGSK NYERSEDPIY VLENNIPIDT KYYLDNQLAN
     PLGRIFEPIL GEKKASQLLT GEHTRAISVA APTMGGLMKF AKKTQTCLGC KKPLSGKEEA
     EGAVCAYCRP RLGELYTKSL TKVSDLEVRF GRLWTQCQRC QGSLHCEVIC SSRDCPIFYM
     RMKAKKDVED AQKELSRFDN DAGAW
//
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