ID A0A100IQC6_ASPNG Unreviewed; 1284 AA.
AC A0A100IQC6;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
GN ORFNames=ABL_08053 {ECO:0000313|EMBL:GAQ45392.1};
OS Aspergillus niger.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=5061 {ECO:0000313|EMBL:GAQ45392.1, ECO:0000313|Proteomes:UP000068243};
RN [1] {ECO:0000313|Proteomes:UP000068243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An76 {ECO:0000313|Proteomes:UP000068243};
RX PubMed=26893421; DOI=10.1128/genomeA.01700-15;
RA Gong W., Cheng Z., Zhang H., Liu L., Gao P., Wang L.;
RT "Draft genome sequence of Aspergillus niger strain An76.";
RL Genome Announc. 4:E0170015-E0170015(2016).
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU003722}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAQ45392.1}.
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DR EMBL; BCMY01000016; GAQ45392.1; -; Genomic_DNA.
DR PaxDb; 5061-CADANGAP00013302; -.
DR VEuPathDB; FungiDB:An17g01550; -.
DR VEuPathDB; FungiDB:An17g01560; -.
DR VEuPathDB; FungiDB:ASPNIDRAFT2_1152622; -.
DR VEuPathDB; FungiDB:ATCC64974_65360; -.
DR VEuPathDB; FungiDB:ATCC64974_65370; -.
DR VEuPathDB; FungiDB:M747DRAFT_314993; -.
DR OMA; MSHILFA; -.
DR Proteomes; UP000068243; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004709; NaH_exchanger.
DR NCBIfam; TIGR00840; b_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF187; SODIUM/HYDROGEN EXCHANGER; 1.
DR Pfam; PF13347; MFS_2; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR PRINTS; PR01084; NAHEXCHNGR.
DR SUPFAM; SSF103473; MFS general substrate transporter; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU003722};
KW Ion transport {ECO:0000256|RuleBase:RU003722};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003722}.
FT TRANSMEM 52..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 447..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 615..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 649..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 678..697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 709..731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 743..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 774..793
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 813..839
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 851..867
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 904..923
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 935..960
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 981..1004
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1010..1032
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 625..1036
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1067..1119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1144..1169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1184..1255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..531
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1094..1111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1153..1167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1202..1235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1284 AA; 140724 MW; 07A5D734E1F115B4 CRC64;
MPETHERFAD ETSPLVGASD NNQVHSMSRN GDNNGTSGAG DAHPLSETKS SWYLFLLTLS
IGGLQVVWST ELSNGSPYLL SLGMSKALLA FVWIAGPITG TLVQPYIGIC SDNCRISWGK
RKPFMVVGGI ATVISLLALA WVKEMTGGFL GLFGVDPASS ATRTVVIVLA TILMYCLDFS
VNTVQAGIRC FIVDNAPSHQ QEAANAWASR LTGVGNILGY IFGYMDLPKW FPFLGNTQFK
VLCALASVAL GITLLVSCLY IKERDPRLDG MPSSGNPGLV TFFKHVFKSI KHLPPEIAKV
CEVQLAAWVG WFPFLFYSTT YIGQLFVNPI FDGHPGLSDD DINKAWEEAT RIGTFALLVY
AIISFVTNLT LPVLVVPTYK SAVPSEPTPT EGESEDEPFL GNRRLSTSSI STAMEAPAPI
LGIDKGDSGE NKWLAKLQIP GFTLRRAWLM SHILFAVCMF STFFIYSYQA ATVVIGIVGI
SWALTLWAPF ALISAEVSRI DTERRIRRHQ NMGAVSEQPR DDTRLPARAN TDEQDLENGS
PNSTTKAGEV EEEENLAQAG IILGLHNVAI SAPQIISSLI SSAIFKAFQK PRGRAVDSDT
DPDDDAPDTG DKEFFSSWAL FILIMLLMFA LFTSYILQQK KIQAVHETVL SIFAGMFVGL
IIRLSPESPI QDSVTFDYQF FFNLLLPPII LASGYELHQA NFFRNIGTIL TFAFAGTFIS
AIVLGLVLFV WTRIPLDGLN ISFVEAIAVG ATLSATDPVT ILAIFNLYKV EPKLYTVIFG
ESILNDAIAI VLFETAQKYA DSDAGSLTFL NLFEAIGVFL LVFFGSMMVG IIVGIMTALG
LKYTHVRRQP KIESCLIVLI AYASYFFSNG VYLSGIVSLL FCGITLKHYA YYNMSRRTQL
TTKYLFQVMA QLSENFIFIY LGLDLLVQRH LQFKPLFILV AVFGICIARY LAVFPLSKAI
NWFIRYRARR RGMDVADELP FAYQAMLFWA GLRGAVGVAL AAGLKGVNAP ALRATVLVVV
VLTVIIFGGT TARMLEILGI RTGVVEEIES DDEFDIEVTN GGTYYKRSDT GLGYTPRRMD
STIPLDGVPR GDIDRNNSYS SGNNRRPSPP PSGSGRTRGH ARLYSNAYSQ RDSGRDRTST
ATLLGGAARS HSDSDVASED EFGLRTTGKN RVADADQLDT FDLDVEDAPS DDDLPPSAPA
PTTSRLRRSP SQPQQYLEPS QTTPPNNTSP NRRETGLSAR DAIRDLFSGG PSGDHAAWFR
QLDEDYIKPR LLLDQSNHKG PGAV
//