ID A0A100IQV6_ASPNG Unreviewed; 909 AA.
AC A0A100IQV6;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=fumarate hydratase {ECO:0000256|ARBA:ARBA00012921};
DE EC=4.2.1.2 {ECO:0000256|ARBA:ARBA00012921};
GN ORFNames=ABL_08348 {ECO:0000313|EMBL:GAQ45687.1};
OS Aspergillus niger.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=5061 {ECO:0000313|EMBL:GAQ45687.1, ECO:0000313|Proteomes:UP000068243};
RN [1] {ECO:0000313|Proteomes:UP000068243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An76 {ECO:0000313|Proteomes:UP000068243};
RX PubMed=26893421; DOI=10.1128/genomeA.01700-15;
RA Gong W., Cheng Z., Zhang H., Liu L., Gao P., Wang L.;
RT "Draft genome sequence of Aspergillus niger strain An76.";
RL Genome Announc. 4:E0170015-E0170015(2016).
CC -!- SIMILARITY: Belongs to the class-II fumarase/aspartase family. Fumarase
CC subfamily. {ECO:0000256|ARBA:ARBA00009084}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAQ45687.1}.
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DR EMBL; BCMY01000017; GAQ45687.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A100IQV6; -.
DR PaxDb; 5061-CADANGAP00010018; -.
DR VEuPathDB; FungiDB:An12g07850; -.
DR VEuPathDB; FungiDB:An12g07860; -.
DR VEuPathDB; FungiDB:ASPNIDRAFT2_1119260; -.
DR VEuPathDB; FungiDB:ASPNIDRAFT2_1133528; -.
DR VEuPathDB; FungiDB:ATCC64974_35200; -.
DR VEuPathDB; FungiDB:ATCC64974_35210; -.
DR VEuPathDB; FungiDB:M747DRAFT_313986; -.
DR VEuPathDB; FungiDB:M747DRAFT_340037; -.
DR Proteomes; UP000068243; Unassembled WGS sequence.
DR GO; GO:0045239; C:tricarboxylic acid cycle enzyme complex; IEA:InterPro.
DR GO; GO:0004333; F:fumarate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0006106; P:fumarate metabolic process; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR CDD; cd01362; Fumarase_classII; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR HAMAP; MF_00743; FumaraseC; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013094; AB_hydrolase_3.
DR InterPro; IPR005677; Fum_hydII.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR018951; Fumarase_C_C.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR NCBIfam; TIGR00979; fumC_II; 1.
DR PANTHER; PTHR11444; ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE; 1.
DR PANTHER; PTHR11444:SF1; FUMARATE HYDRATASE, MITOCHONDRIAL; 1.
DR Pfam; PF07859; Abhydrolase_3; 1.
DR Pfam; PF10415; FumaraseC_C; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
FT DOMAIN 118..341
FT /note="Alpha/beta hydrolase fold-3"
FT /evidence="ECO:0000259|Pfam:PF07859"
FT DOMAIN 454..785
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 851..903
FT /note="Fumarase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF10415"
SQ SEQUENCE 909 AA; 99795 MW; 3224F6F24B5EFF39 CRC64;
MPALNDEKTL RELRPRVLLQ PLHNSIPSEL LPRFDPVYVE HYNKYNAGRL HTHEVPIEEF
RKNPAKYAIV YGRAQGPDIF RITEQKCPVE GGEITIRIFE PAPKLDEHGK AKKRAAYVNF
HGGGWVFGDL SVDHDFCKTL VDGLDGQLVA FDVDYRLAPE HKYPIPVDDC WAAFNWIRSQ
KAEEFNVDPD RMAVGGCSAG GHLSAVVAHL CRNAGIPLRL QVLNVPVCDL HSGYTPDGDF
DRENCPYESY REMEFTAALP VARMAYFHRH FLGVPRPARS EEDWKISPMF APDFSGLAPA
LVFTAEMDPL RDEGEGYAAK LKAAGCRVEM MRMAGAPHTF AMLDGIMESG RIYIEKNQKP
VVMLTSAHTS RAAVRSMASL THAASRASAS PAVARTAVAF TPASFSCRRL LSSNSRPVQQ
FPRLQSLTST SSKRAFGTTV KMSSATRIET DAFGEIEVPA DKYWGAQTQR SLGNFDINQP
QDRMPEPVVK AFGILKGAAA EVNMKFGLDP KIGEAIKQAA AEVAEGKLMD HFPLVVWQTG
SGTQSNMNSN EVISNRAIEI LGGEKGSKKP VHPNDHVNMS ASSNDSFPTA MHIAAVLELE
NTLLPSLRSL RNALQVKVEK FDKIIKIGRT HLQDATPLTL GQEFSGYVAQ LDRNIERVET
SIPHLRYLAQ GGTAVGTGLN TFKGFDEAIA AEVTKLTGTE FKTAPNKFEV LAAHDSIVEA
SGALNTLACS LFKIAQDIRY LGSGPRCGLG ELVLPENEPG SSIMPGKVNP TQCESLTMVC
SQVMGNHVAA TVGGMNGQFE LNVFKPLMIR NLLHSVRILA DGMTSFEKNL VHGLEANEPR
INSLLHESLM LVTCLNPVIG YDMASKVAKN AHKKGLTLKQ SAMELKALSE EDFDKHVRPE
LMLSPKEKK
//
