ID A0A100ISA1_ASPNG Unreviewed; 386 AA.
AC A0A100ISA1;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Alcohol dehydrogenase {ECO:0000313|EMBL:GAQ46409.1};
GN ORFNames=ABL_09070 {ECO:0000313|EMBL:GAQ46409.1};
OS Aspergillus niger.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=5061 {ECO:0000313|EMBL:GAQ46409.1, ECO:0000313|Proteomes:UP000068243};
RN [1] {ECO:0000313|Proteomes:UP000068243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An76 {ECO:0000313|Proteomes:UP000068243};
RX PubMed=26893421; DOI=10.1128/genomeA.01700-15;
RA Gong W., Cheng Z., Zhang H., Liu L., Gao P., Wang L.;
RT "Draft genome sequence of Aspergillus niger strain An76.";
RL Genome Announc. 4:E0170015-E0170015(2016).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAQ46409.1}.
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DR EMBL; BCMY01000021; GAQ46409.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A100ISA1; -.
DR PaxDb; 5061-CADANGAP00009337; -.
DR VEuPathDB; FungiDB:An12g00670; -.
DR VEuPathDB; FungiDB:ASPNIDRAFT2_1182853; -.
DR VEuPathDB; FungiDB:ATCC64974_39530; -.
DR VEuPathDB; FungiDB:M747DRAFT_295539; -.
DR OMA; DMPLAQY; -.
DR Proteomes; UP000068243; Unassembled WGS sequence.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd05283; CAD1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR047109; CAD-like.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42683; ALDEHYDE REDUCTASE; 1.
DR PANTHER; PTHR42683:SF3; DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01980)-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 35..166
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 215..342
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 386 AA; 41980 MW; 61A4AEA16845511E CRC64;
MSPPSPPEHF HGYLSNSPTT PLTYAPYTPK PFTPTDIEIN ITHCGICGTD LHTLRSGWGP
NTTTYPCIVG HEIIGIVTRI GSSIPTSPAY PNTTPLRIGD RVGIGAQTLS CLQPSCEECV
AGKENYCPRI TGTYNSRYWD NETGKRSDVI AYGGFARKWR GPAAFAFRIP ERLESEVAAP
LLCAGTTVFA PLRKYLGDGA DSGKGKTVAV VGIGGLGHLG IMFAKALGCE RVIGISRSNG
KREDAVKGLG ADEFIATGEE KGWEKKWSRS VDLILCTVDG DDMPLGKYLR LLKAGGTFVL
VGAPEKPLPR MRAFELIGKG VNVTGSNIGS REDIRCMLEV AAEKGVRPWV ETRRMEEVNE
ALRDMEEGKA RFRYVLVNGE ERESRL
//
