ID   A0A100W0P6_9MYCO        Unreviewed;       764 AA.
AC   A0A100W0P6;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=MMPL domain-containing protein {ECO:0000313|EMBL:GAS89361.1};
GN   ORFNames=RMCB_3457 {ECO:0000313|EMBL:GAS89361.1};
OS   Mycolicibacterium brisbanense.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=146020 {ECO:0000313|EMBL:GAS89361.1, ECO:0000313|Proteomes:UP000069620};
RN   [1] {ECO:0000313|EMBL:GAS89361.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM15654 {ECO:0000313|EMBL:GAS89361.1};
RA   Katahira K., Ogura Y., Gotoh Y., Hayashi T.;
RT   "Draft Genome Sequences of Five Rapidly Growing Mycobacterium Species, M.
RT   thermoresistibile, M. fortuitum subsp. acetamidolyticum, M. canariasense,
RT   M. brisbanense, and M. novocastrense.";
RL   Genome Announc. 4:e00322-16(2016).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAS89361.1}.
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DR   EMBL; BCSX01000028; GAS89361.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A100W0P6; -.
DR   STRING; 146020.RMCB_3457; -.
DR   Proteomes; UP000069620; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        186..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        238..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        290..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        315..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        380..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        550..571
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        576..594
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        614..634
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        665..685
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          215..340
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   REGION          742..764
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   764 AA;  80257 MW;  7D57CB738CE901FF CRC64;
     MSSAKGTNLL HRIARLAIAA PRLTVSVAAL VMVVAAVFGI PVAKSLSPTG FEDPASESAI
     ATRMLADRFG QGDQQLVFVV SSPDGADSTD ARRTGTAIVD DLHRSPHVAS VTSAWTVPPA
     AAAQLISRDG RSGLVVAGIT GGERDAPNYA NTLSEQILRD HGSVTVRAGG PAMVNAGITE
     QTQKDLLLME SIAIPLSFLV LVWVFGGLLA AALPVMVAVM AIAGALAVLR LITFTTDVSI
     FALNLSTAMG LALAIDYTLL IISRYRDELA DGAGRDDALE RTMVTAGRTV LFSATTVALS
     MAALILFPMH FLKSLAYAGV ATVTFAAIVA VVVTPAVIVL LGTRLDALDV RRLLRRSPPR
     ARPVEQQFWY RSTRFVMRHA ISIGLAVVTL LVLLGVPFLG VKWGFPDDRV LPSSASPHQV
     GDQLRTGFDA DPATSVSVVI PDANGIGPQD ITHYAADLSR VPGITAVSTP MGTFVNGVQT
     GPPSAATGEA QGSVFLTAAS TAPLFSSTSE TQLDQIHALA GPGGRTVYVT GTAQTNRDTV
     NAIMSRLPGV LGVIAVISLL LLFMLTGSVL LPLKALVLNV LSLSAAFGAM VWIFQDGNLG
     GLGTTATGTL VTNMPVVLFC IAFGLSMDYE VFLVSRIREF WLASERTCAA ADESVALGVA
     HTGRVITAAA LVMSISFAAL TAAHVSFMRM FGLGLTLAIL VDATLVRTVL VPAFMHLMGT
     WSWWAPAPLV WLHKHIGITH GEPAPAAPKH RLVPAQRRDS EEVQ
//