ID A0A100Y5R8_9ACTN Unreviewed; 665 AA.
AC A0A100Y5R8;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Squalene--hopene cyclase {ECO:0000313|EMBL:KUH38147.1};
GN ORFNames=ATE80_14375 {ECO:0000313|EMBL:KUH38147.1};
OS Streptomyces kanasensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=936756 {ECO:0000313|EMBL:KUH38147.1, ECO:0000313|Proteomes:UP000054011};
RN [1] {ECO:0000313|EMBL:KUH38147.1, ECO:0000313|Proteomes:UP000054011}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ZX01 {ECO:0000313|EMBL:KUH38147.1,
RC ECO:0000313|Proteomes:UP000054011};
RA Zhang G., Han L., Feng J., Zhang X.;
RT "Genome-wide analysis reveals the secondary metabolome in Streptomyces
RT kanasensis ZX01.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004999}.
CC -!- SIMILARITY: Belongs to the terpene synthase family.
CC {ECO:0000256|ARBA:ARBA00006333}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUH38147.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LNSV01000031; KUH38147.1; -; Genomic_DNA.
DR RefSeq; WP_058942609.1; NZ_LNSV01000031.1.
DR AlphaFoldDB; A0A100Y5R8; -.
DR STRING; 936756.ATE80_14375; -.
DR OrthoDB; 9758578at2; -.
DR UniPathway; UPA00337; -.
DR Proteomes; UP000054011; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR006400; Hopene-cyclase.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01507; hopene_cyclase; 1.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000054011};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 45..329
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 340..655
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 665 AA; 73636 MW; 0865027BEEA60375 CRC64;
MTATTDGSAG ALGPRTIVTT GTHHTTAPAP TPAPDVRTDA ETAMRRSVDH LLGRQDGEGW
WKGDLETNVT MDAEDLLLRE FLGIRDEAVT EAAARFVRGE QRDDGTWATF HGGPGELSAT
VEAYVALRLA GDPPDAPHMA RAAAWVRQRG GIAAARVFTR VWLALFGWWR WEDLPELPPE
LIFLPSWFPL NIYDFGQWAR QTIVPLTIVS AKRPVRPAPF TLDELHTDPR CPNPPRPLAP
AATWDGLFQR LDRALHRYRR VAPRPLRRAA MNAAARWIVE RQENDGCWGG IQPPAVYSLI
ALHLLGYDLG HPVMRAGLES LDRFAVRRED GARMVEACQS PVWDTCLAVI ALADAGLPAD
HPALVRAADW MLAEQVVRRG DWAVRRPHLP PGGWAFEFHN DTYPDIDDTA EVILALRRVR
HPDPDRVDAA VARGARWTLG MQCRDGAWGA FDADNTSPFP NRLPFCDFGE VIDPPSADVT
AHVVEMLAHE GLAHDPRTRR GIAWLLAEQE PRGSWFGRWG VNHVYGTGSV VPALTAAGLP
PAHPAIRRAV AWLESVQNED GGWGEDLRSY REEEWVGRGA STASQTAWAL LALLAAGERN
SAAVGRGVAW LARTQREDGS WDEPYFTGTG FPWDFSINYH LYRQVFPLTA LGRYVRGEPS
FGKGR
//
