ID A0A101A4W4_9MYCO Unreviewed; 393 AA.
AC A0A101A4W4;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:KUI13817.1};
GN ORFNames=AU193_14460 {ECO:0000313|EMBL:KUI13817.1};
OS Mycobacterium sp. GA-1285.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1772282 {ECO:0000313|EMBL:KUI13817.1, ECO:0000313|Proteomes:UP000053702};
RN [1] {ECO:0000313|EMBL:KUI13817.1, ECO:0000313|Proteomes:UP000053702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GA-1285 {ECO:0000313|EMBL:KUI13817.1,
RC ECO:0000313|Proteomes:UP000053702};
RG TB Trials Study Group;
RA Sutton G., Brinkac L., Sanka R., Adams M., Lau E.L., Macaden R.,
RA Grewal H.M.S.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUI13817.1}.
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DR EMBL; LQIS01000035; KUI13817.1; -; Genomic_DNA.
DR RefSeq; WP_064423625.1; NZ_LQIS01000035.1.
DR AlphaFoldDB; A0A101A4W4; -.
DR STRING; 1772282.AU193_14460; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000053702; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:KUI13817.1}.
FT DOMAIN 10..261
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 271..392
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 96
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 349
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 379
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 393 AA; 40647 MW; C2C4C8C7D1EFDAB5 CRC64;
MSGFSGRDAV IVGAVRTPTG KGKPNGALHD VLPVDLLAHS LTELVARTGI DPVQIDDVIA
GAVTQVGDQA VNIARNALLG AGFPESVPGT TVDRQCGSSQ QAIHFAAAGV ISGAYDIVVA
AGVESMSRAP MGSSVLPGSD PFGAMAQRYP EGLVPQGISA ELIAAKWGLS RQQLDEFSAG
SHEKAAAATK EGRFDNELIP INGLTTDEII RPGTTVDTLA ALNPAFYNPA YERRFPQIGW
KITPGNSSPL SDGSAAVLIT TGEVAARLGL RPLARIHSMT VVGSDPLYML TGVIPATEKV
LQRAGLTLAD IDLFEVNEAF APVVLSWAHD TGADLARTNV NGGAIAIGHP LGASGARIMT
TLVNALEQRG GRYGLQTMCE GGGMANATVI ERL
//
