ID A0A101APZ1_9MYCO Unreviewed; 519 AA.
AC A0A101APZ1;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000256|HAMAP-Rule:MF_00212};
DE EC=1.1.5.4 {ECO:0000256|HAMAP-Rule:MF_00212};
DE AltName: Full=MQO {ECO:0000256|HAMAP-Rule:MF_00212};
DE AltName: Full=Malate dehydrogenase [quinone] {ECO:0000256|HAMAP-Rule:MF_00212};
GN Name=mqo {ECO:0000256|HAMAP-Rule:MF_00212};
GN ORFNames=AU194_04570 {ECO:0000313|EMBL:KUI26772.1};
OS Mycobacterium sp. GA-2829.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1772283 {ECO:0000313|EMBL:KUI26772.1, ECO:0000313|Proteomes:UP000053444};
RN [1] {ECO:0000313|EMBL:KUI26772.1, ECO:0000313|Proteomes:UP000053444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GA-2829 {ECO:0000313|EMBL:KUI26772.1,
RC ECO:0000313|Proteomes:UP000053444};
RG TB Trials Study Group;
RA Sutton G., Brinkac L., Sanka R., Adams M., Lau E.L., Macaden R.,
RA Grewal H.M.S.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001139, ECO:0000256|HAMAP-
CC Rule:MF_00212};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|HAMAP-Rule:MF_00212};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC oxaloacetate from (S)-malate (quinone route): step 1/1.
CC {ECO:0000256|ARBA:ARBA00005012, ECO:0000256|HAMAP-Rule:MF_00212}.
CC -!- SIMILARITY: Belongs to the MQO family. {ECO:0000256|HAMAP-
CC Rule:MF_00212}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUI26772.1}.
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DR EMBL; LQIT01000045; KUI26772.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A101APZ1; -.
DR STRING; 1772283.AU194_04570; -.
DR OrthoDB; 9763983at2; -.
DR UniPathway; UPA00223; UER01008.
DR Proteomes; UP000053444; Unassembled WGS sequence.
DR GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR HAMAP; MF_00212; MQO; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006231; MQO.
DR NCBIfam; TIGR01320; mal_quin_oxido; 1.
DR PANTHER; PTHR43104; L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43104:SF2; L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF06039; Mqo; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|HAMAP-Rule:MF_00212};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630, ECO:0000256|HAMAP-
KW Rule:MF_00212};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002, ECO:0000256|HAMAP-
KW Rule:MF_00212}; Reference proteome {ECO:0000313|Proteomes:UP000053444};
KW Tricarboxylic acid cycle {ECO:0000256|HAMAP-Rule:MF_00212}.
FT REGION 493..519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 519 AA; 56542 MW; E90A823330107437 CRC64;
MSDSQVAKTD VVLVGAGIMS ATLSVLLKQL EPNWTITLIE RLDGAAAESS FAWNNAGTGH
SALCELNYTP EGPGGSIDIT KAVNVNEQFQ VSRQFWTHAV ENGVLPDVRN FINPVPHVSF
VSGEKNRQYL RARYDALVTN PLFATMEYID DPDEFARRLP FMADKRDFRE PIALNWTQDG
TDVDFGSLSR QLIGYSAQRG MTTLFGHEVR DLDKQSDGSW AVKVRNRRTG AKRKLNAKFV
FVGAGGGALP LLQKAGIEEA KGFGGFPVGG QWLRSDNPEL TARHQAKVYG MPPLGAPPMS
VPHLDTRVIN SKSYLLFGPF AGWSPKFLKQ GKVTDLPFSV RPNNLASMLG VGLTEMGLLK
YLIGQLMLSE ADRVESLRDF APSARDADWE LDIAGQRVQV IRRKGRGGVL EFGTTVLAAK
DGSIAGLLGA SPGASTAVPA MFDVMQRCFG DRYRAWEPKL KEIVPSLGTK LSDEPKLFEE
IWAHGTKVLK LDRPAAGLPA TGSDTEHPTP DASRTTATA
//
