ID A0A101B960_9MYCO Unreviewed; 643 AA.
AC A0A101B960;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Acetoacetyl-CoA synthetase {ECO:0000313|EMBL:KUI36878.1};
GN ORFNames=AU194_22695 {ECO:0000313|EMBL:KUI36878.1};
OS Mycobacterium sp. GA-2829.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1772283 {ECO:0000313|EMBL:KUI36878.1, ECO:0000313|Proteomes:UP000053444};
RN [1] {ECO:0000313|EMBL:KUI36878.1, ECO:0000313|Proteomes:UP000053444}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GA-2829 {ECO:0000313|EMBL:KUI36878.1,
RC ECO:0000313|Proteomes:UP000053444};
RG TB Trials Study Group;
RA Sutton G., Brinkac L., Sanka R., Adams M., Lau E.L., Macaden R.,
RA Grewal H.M.S.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUI36878.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LQIT01000012; KUI36878.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A101B960; -.
DR STRING; 1772283.AU194_22695; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000053444; Unassembled WGS sequence.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd05943; AACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053444}.
FT DOMAIN 36..87
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 94..462
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 529..604
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 643 AA; 69143 MW; 86112A7D32AF481C CRC64;
MTEPQWVPTE ADVAGARVTD FARFVQQRTG IEMPDYHALW QWSVDDLAGF WGALWEYFEL
GDAPAEVLAE EAMPGARWFP GTRLNYVDQV VRHARSDRPA ILYVAEGGAV TEMAWDEMLS
RAAGLANTLR SLGVGSGDRV VGYLPNVPEA VIAFLATVSL GAIWSACGQD YTAKAALDRL
GQLEPVVLIA ADGYRFGGKT HDKTADVAAL RAGLPTVRGA VLVSRIGADV PGSDWLDWAT
ATADGGRLEP VAVDFDHPLW VLYSSGTTGL PKGIVHGHGG VVVEHLKAVA LQADIGPDDT
FFWFTSPSWM MWNFQVAGLL VGATIVCYDG SPTYPAADTL WAIAADVGAT VLGTSPGYVL
ACEKAGAVPR KDHDLSALRT VGITGSSLPP ASALWLRDNV GVQVASISGG TDVVSAFIGG
VRTVPVWPGE LSAPYLGAAV EAWDTSGDPV HGEVGELVIT KPLPSMPVKF WNDPDGSRYR
DAYFETYPGV WRHGDWITIT DHGSVIVHGR SDSTLNRHGI RMGSADIYQA VERMPEVAEA
LVIGAEQPDG GYWMPLFVTL ADGAELTDEL RDRICQTIRT EVSPRHVPDE IVLAPGIPHT
RTGKKLEVPI KKLLQGGDPA RVVEPTAVDD PTLLDWYVTQ RRT
//
