ID A0A101GTW7_9FIRM Unreviewed; 800 AA.
AC A0A101GTW7;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 13-SEP-2023, entry version 19.
DE SubName: Full=DNA internalization-related competence protein ComEC/Rec2 {ECO:0000313|EMBL:KUK64595.1};
GN ORFNames=XD84_1318 {ECO:0000313|EMBL:KUK64595.1};
OS Desulfotomaculum sp. 46_80.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Desulfotomaculaceae;
OC Desulfotomaculum.
OX NCBI_TaxID=1641375 {ECO:0000313|EMBL:KUK64595.1, ECO:0000313|Proteomes:UP000053828};
RN [1] {ECO:0000313|Proteomes:UP000053828}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=26787827; DOI=10.1128/mbio.01669-15;
RA Hu P., Tom L., Singh A., Thomas B.C., Baker B.J., Piceno Y.M.,
RA Andersen G.L., Banfield J.F.;
RT "Genome-Resolved Metagenomic Analysis Reveals Roles for Candidate Phyla and
RT Other Microbial Community Members in Biogeochemical Transformations in Oil
RT Reservoirs.";
RL MBio 7:e01669-15(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUK64595.1}.
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DR EMBL; LGGF01000024; KUK64595.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A101GTW7; -.
DR PATRIC; fig|1641375.3.peg.1065; -.
DR Proteomes; UP000053828; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 41..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 432..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 501..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 535..751
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 800 AA; 87282 MW; 80E47DA0284A37D9 CRC64;
MLFTSILIFG IVLSGYLNIS PGFLLLLLGI AFFAAVTGYL FSWKASGIVF SLLFFLTGIF
YGTISNNRVN PDLFRYTGHW VTLEGVVCSE PDLRQDKVFY KLDLTGIKIG EEQSRLKARV
LVQAPKPDKV YCFGDLLRIH GLLVRPDEPG NPGEFDYRTY LTRQGIGVIL RASGSEDFVL
LGVRGNLFMR QLLLLKKKII MVQQQTLPDD KAALVNGIVF GTQGQIPENL WEAFSQTGIV
HILSVSGMHV GLVLAGAIAL TGLLNIPGIQ GTLLISLLVV LYSLFCGMGP AVTRSALMAL
MFLWSHRLGR KQDWPTTLSL AALIILLWKP AAIYDIGFQL SFSATWGILY LGPVIDELLK
KHTRWPAWVQ ATIWVSLAAQ LATLPLVALY YNLFSPVSML ANILAVPLTT LILALGVCSG
ILGLFSVFLA GLINACTSAV LDIFIAVVSL LNSLPGSFIS VPSPPLIVIP VWFIVLFFSA
RIFNKKNASI IVRFLSEKRN TAVLILILAV TVISLLFFKT PAEKQLVMHM IDVGQGESIL
IQFPSGKNML VDTGGWDGEF ATGEGAGSKV VLPYLQRLGV RRLDALLLTH SHEDHAGGAA
AVVNSIPAAL VIVSSAAQKA NSLSGASPEE DPYSRLLEGF RKKGILIQAV NEGDRLLLDR
DVEIKVLSPS PARSYQADDE NNSSVVLMIR YGRQKFLLTG DIEVEAQESL LKSGADLRAD
ILKAPHHGSK LIRPFVERVH PSLALISVGN HNRFFLPRPE TVKLLKDLNI PVYRTDKDGA
IILSANGSKI RVKTGRGTGS
//
