ID   A0A101J9E6_9ACTN        Unreviewed;      1010 AA.
AC   A0A101J9E6;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:KUL22619.1};
GN   ORFNames=ADL12_41810 {ECO:0000313|EMBL:KUL22619.1};
OS   Streptomyces regalis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=68262 {ECO:0000313|EMBL:KUL22619.1, ECO:0000313|Proteomes:UP000053923};
RN   [1] {ECO:0000313|Proteomes:UP000053923}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 3151 {ECO:0000313|Proteomes:UP000053923};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUL22619.1}.
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DR   EMBL; LLZG01000395; KUL22619.1; -; Genomic_DNA.
DR   RefSeq; WP_062713299.1; NZ_LLZG01000395.1.
DR   AlphaFoldDB; A0A101J9E6; -.
DR   OrthoDB; 9772207at2; -.
DR   Proteomes; UP000053923; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR   Gene3D; 2.60.40.2220; -; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR041147; GH38_C.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF17677; Glyco_hydro38C2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053923}.
FT   DOMAIN          519..597
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   1010 AA;  111311 MW;  C5C85C1C1962CDB0 CRC64;
     MHDDRSLVEA RLKRVLDERI RPAVYPESVP LDVAVWHAPG EPVPVAEGLA AEPEPIEVGA
     RWGAPWGTSW FRVTGTVPEA WAGKTVEALL DLGFDENMPG FQCEGLVYRP DGTPVKGLNP
     RNQWVRIGAP VAGGEEVRLH IEAASNPVIL DYHPFLPTQL GDKETAGSEP QYTLTRMDLA
     VLDEDVWQLV IDLEVLGELM AELPVESARR WEILRAVEKA LDAVDLQDVG GTAARARERL
     ADVLATPAVP SAHRISAVGH AHIDSAWLWP LRETVRKVAR TTSNMTALIE DEPDFVFAMS
     QAQQWAWVKE HRPEVWARVK KAVADGRFVP AGGMWVESDT NMPGSEAMAR QFVHGKRFFL
     DEFGIENDEA WLPDTFGFAA GLPQIIKAAG SKWLLTQKIS WSQTNKFPHH TFQWEGIDGT
     RIFTHFPPVD TYNCSMKGSE IAHAARNFKD KGAARHSLAP TGWGDGGGGT TREMVAKAAR
     LRSLEGSATV TWETPAEFFA KAEAEYPDAP VWVGELYLEL HRATLTSQAK TKQGNRRSEH
     LLREAELWAA TAAVRTGFPY PYEELDRIWK TVLLHQFHDI LPGSSIAWVH REARATYERL
     AGGLNAIIES AQRALAGEGE TELVFNGAPH PRDGVPAGGA RTPLTEGRTA LTALTARQGG
     GFVLDNGLLR IEIDAQGLVV SAFDIEADRE TVAPGRAAGL LQLHPDFPNM WDAWDVDEFY
     RSTVTDLTGA DEVTPGDDEG AVRIVRSFGA SRVTQVLSLA PGERRLLLDT EVDWHETEKF
     LKLAFPLDLH AERYASETQF GHFFRPTHTN TSWEAAKFEA CNHRFVHLEE PGWGVAVVND
     STYGHDVTRT VRTDGDRGTT TTVRVSLLRA PRFPDPETDQ GVHRFRHALV PGAGIGDAVR
     EGWRINLPER SVSGAREVAP LATVDREAVV ITAVKLADDG SGDVVVRLHE AQGGRVRATL
     AADFEVTDVT ATDLLERPLP EAPSCDGARV ALRLRPFELV TLRLRRAPVH
//