ID A0A101JBJ0_9ACTN Unreviewed; 850 AA.
AC A0A101JBJ0;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=ADL12_38960 {ECO:0000313|EMBL:KUL23753.1};
OS Streptomyces regalis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=68262 {ECO:0000313|EMBL:KUL23753.1, ECO:0000313|Proteomes:UP000053923};
RN [1] {ECO:0000313|Proteomes:UP000053923}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 3151 {ECO:0000313|Proteomes:UP000053923};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL23753.1}.
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DR EMBL; LLZG01000384; KUL23753.1; -; Genomic_DNA.
DR RefSeq; WP_062712030.1; NZ_LLZG01000384.1.
DR AlphaFoldDB; A0A101JBJ0; -.
DR OrthoDB; 9806130at2; -.
DR Proteomes; UP000053923; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR InterPro; IPR006016; UspA.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR Pfam; PF00582; Usp; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KUL23753.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053923};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 380..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 622..835
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 850 AA; 91187 MW; 4360DBA550D2D383 CRC64;
MARGKLRIYL GAAPGVGKTY AMLSEAHRRV ERGTDCVVAF VEHHSRPRTE VMLHGLEQIP
RKELEYRGSV FTEMDVDAVL ARRPQVALVD ELAHTNIPGS RNSKRWQDVE ELLAAGIDVI
SAVNIQHLES LGDVVESITG IRQKETVPDE VVRRTDQIEL VDMSPQALRR RMAHGNIYKP
DKVDAALSNY FRPGNLTALR ELALLWVADR VDEYLQQYRS EHQVSTIWGS RERIVVGLTG
GPEGRTLIRR AARLAEKGAG GEVLAVYIAS SDGLTSASPK ELAVQRTLVE DLGGTFHHVV
GDDIPVALLE FARAVNATQI VLGVSRRKSW QYIFGPGVGA TVARDSGPDL DVHLITHDEA
GKGRGLPAAR SARLGRSRLI WGWLTGVAGP ALLTLLLSSV LPELGLANDM LLFLTLTVAA
ALLGGLLPAL ASAMVGSLLL NWFFTSPVHT LTIADPKNIV AIAVFVGVAV SVASVVDLAA
RRTEQAARLR AESEILSYLA GSVLRGETGL EELLERVRET FGMRSAALLE RENDTAPWSC
AGRVGESPVV GRPEDADVDV PVGDHMALAL SGRVLPASDR RVLSAFAAQA AVVLDRQRLQ
SEADQARELA EGNRIRTALL AAVSHDLRTP LAGIKASVSS LRSDDVEWSE EDQAELLAAI
EEGADRLDHL VGNLLDMSRL QTGTLTPLIR EIDLDEVVPL ALGGIPDPDE TVGLDIPETL
PMVATDKGLL ERVVANVVEN AVKYSPEDEP VLVAASAIAD RVEVRVVDRG PGVPDEAKDR
IFAPFQRYGD APRGNGVGLG LAVARGFAEA MGGTIHAEDT PGGGLTMVLS LPTAADRQPV
TADLPVTATS
//
