ID A0A101N7A8_9ACTN Unreviewed; 325 AA.
AC A0A101N7A8;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Pyruvate dehydrogenase (Acetyl-transferring) E1 component subunit alpha {ECO:0000313|EMBL:KUM87855.1};
GN ORFNames=AQI94_15105 {ECO:0000313|EMBL:KUM87855.1};
OS Streptomyces pseudovenezuelae.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces aurantiacus group.
OX NCBI_TaxID=67350 {ECO:0000313|EMBL:KUM87855.1, ECO:0000313|Proteomes:UP000053039};
RN [1] {ECO:0000313|EMBL:KUM87855.1, ECO:0000313|Proteomes:UP000053039}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40212 {ECO:0000313|EMBL:KUM87855.1,
RC ECO:0000313|Proteomes:UP000053039};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces pseudovenezuelae DSM 40212, type
RT strain for the species Streptomyces pseudovenezuelae.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUM87855.1}.
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DR EMBL; LMWM01000013; KUM87855.1; -; Genomic_DNA.
DR RefSeq; WP_031057868.1; NZ_KQ948146.1.
DR AlphaFoldDB; A0A101N7A8; -.
DR OrthoDB; 9766715at2; -.
DR Proteomes; UP000053039; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Pyruvate {ECO:0000313|EMBL:KUM87855.1}.
FT DOMAIN 12..308
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
SQ SEQUENCE 325 AA; 34700 MW; 800499FFB102FB89 CRC64;
MDTGELLALY EQMALIRRTE KAAHDLFLQG LVKGTTHLAA GHEAIAVGAS AALRDDDYVF
ATYRGHHHAL ARGATPEECL AELMSRATGL CGAKGGSMHL TKAATNMLGS YAIVGAHLPM
AVGAAWSAKL RGTGQLAVAF FGDGATNIGA FHEALNLAAV WKLPVLFVCE NNLYMEYTPI
ADVTAVPRPA ADRASAYGIP GEVVDGNDVV SVLETVARLA RRARAGEGPA LLEAETYRHF
GHSRTDPATY RPAEEVERWL KHDPLDIARG RLVEAGVPEE TVAEADDRAR TVVQRAVEAA
RNAPSPDPRE AFTDVWADGG AAWRT
//
