ID A0A101NJJ1_9ACTN Unreviewed; 2339 AA.
AC A0A101NJJ1;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Polyketide synthase {ECO:0008006|Google:ProtNLM};
GN ORFNames=AQI95_43630 {ECO:0000313|EMBL:KUM94154.1};
OS Streptomyces yokosukanensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=67386 {ECO:0000313|EMBL:KUM94154.1, ECO:0000313|Proteomes:UP000053127};
RN [1] {ECO:0000313|EMBL:KUM94154.1, ECO:0000313|Proteomes:UP000053127}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40224 {ECO:0000313|EMBL:KUM94154.1,
RC ECO:0000313|Proteomes:UP000053127};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces yokosukanensis DSM 40224, type
RT strain for the species Streptomyces yokosukanensis.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUM94154.1}.
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DR EMBL; LMWN01000125; KUM94154.1; -; Genomic_DNA.
DR STRING; 67386.AQI95_43630; -.
DR OrthoDB; 3488622at2; -.
DR Proteomes; UP000053127; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd08953; KR_2_SDR_x; 1.
DR CDD; cd00833; PKS; 2.
DR Gene3D; 1.10.1240.100; -; 2.
DR Gene3D; 3.40.47.10; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 2.
DR Pfam; PF00109; ketoacyl-synt; 2.
DR Pfam; PF02801; Ketoacyl-synt_C; 2.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 3.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 2.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000053127};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 450..529
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 599..1013
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1654..1728
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1775..2182
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 419..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1727..1769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2339 AA; 250635 MW; CC7A4CCC9B2F00F2 CRC64;
MESLAPRYTD IGAPAVSDVR GEQAGATVVV TDREDVASAA RSIGAECWYG DPATESEERL
GQELRRLAAH CTTLVVAWGD GPSGGTPQYG PAIRFARAAL ALLQAVRESG RRVHLVTLSR
TAEVLPSLLD GMARTAALEC PLLHTAVEWS DPVTPERLRG WIAAGARHPG AVLRAEGERI
ARLEHAPRPP AGVPSREVFR DGDPVVVIGG AGGVGRHLCR YLSRHHGAQV FVLGRGTPGP
QAQAALKEAG VRSYLGAPAH DREALDGALR YIHDRFGPVK AVFNLAGVLD DCLLYNLTPD
RLETVLRPKV ATGLNLASLS GPHRPGMVVH FSSLTSVTGN VGQAAYGAAN AFLDRLSEHR
SDWYSINWGL WDTDGMQMPD DGSGLRAMDP EQACDALMSA LATGTRHLVV YDGQVRLATD
AAPPSAPPSE SPSVSPGADA PAGAASPAPD LLAGTTRWLR ELMIRHSGLR HLRDDENLLD
QGLDSIASIR ISRDIEGCLD IAGSSRLSRA VLFEYPTVSA LCAYLIENFA AELETFLARE
PQPAPESAAA PAPTTEAAPP APTVPTAAAT PRQLAQEWRE SPSAAAPRED APAPDAYRPD
DIAIIGMAAE FPGGADTEAF WQALLRGDDA VRVIPGDRWD WRENHSFAPD EPGTSYGRHG
GFLDHALDFD PVFFNIAPLE ARFMDPQERR FLQSVYHALE DSGHFARPTD DVGVFVAAMF
GHYQDLTAPD RVIGSSFAAI ANRVSYAFDL HGPSVALDTM CSGGLTALHL AVRSIRAGDC
ALAVAGGVNL MTHPGKYRLL SEGKFLSPTG HCQAFGVEAD GYVPGEGTAA VVLKPLSEAL
RDGDRVHAVI RATAVNSGGR TAGFTVPSER AQHRVITSAL AAAEIEPGAV TYVEAHGTGT
RLGDPIEARA LRQAYGGAEQ GRAYLGSVKS NIGHLESAAA LAGLVKVVKQ LAHRTLAPTL
HCELENPDLH LQDSRFALVK ETLPWPKGSG PTRFAGLSSF GAGGANGHAI IQEFVAPRES
GPVPEFPRYF IPLSGRDEAA VRRRADELLA ALGDAPDTAS YLYGLSYTLS CARQHFRVRR
GYWATSVRQL AGLLQSADAT SPTSPAAPAA GDPDPWATAA SAYLDGESPD FTRLFPLRML
VDAPLYPFAR ERYVADTLDH ANRPSARTAP AAPAPGTVGD AAALLLTPVW HPRPADDPAD
ATVPYVLVLT DRGRQRRLPD PPEGTRLIRV MPGDELVVGA DRIELPDGDD TAARRALDHL
TGELGLEHLY WVDLRREASV ASQLSFAKAL QGCRTPSTVL GATREADPAE ARAGAGFLHG
LAEENPHVRT VQARRSGAGD VLADGWGPLL DELCAAREPL TEVRWADGTR QRRELAELGL
ADGVRLRTGG TYLLTGGLGK VGRAIADLLT ERYRATVIAV GRSAPDAGQR QWIDASPGLH
YEQADIVSAP RTRELIETIR ERFGGLDGVI HSAGVIRDAL VQNKSAEDAQ AVLAPKVQGT
LNLDRYTAEL PLDFFCVFSS ISSVMGNTGQ SDYIAANRFL DEFAAERARR VADGERSGLS
LSVNWPLWLD AEDARREQYE ALAHFLRGQF GMEPLSSRRG AQLFLDLLDG LPASCHQVIP
CVGDVRRMRQ RLLPGTGRPV PRADRTTRAA ATLEEISERL VELVGVTTGL RPEDIAFDST
WGDLGYDSVM LQNLARELGP RFGVETPPNA LFKYSTVTSL STYLRDQGAP AQGQEPAAPR
PSPSAGAARS TGAGTATDTA PAARTGRGDL ADGGRGRYAV VGMNGIMPGG ANLADFWRLL
VENGSAVRAV DRWKDREKQY FAGTIDDFDA FDHSFFGLSA REAMLMDPQH RLFLQSAYNA
LLDAGYAPGS LREVGVFAGV QFSEYQTALQ HSEDWAHPYT VTGNAHAMLA NRVSHLLDFT
GPSQTVDTAC SSGLVALNRG VLSLAAGECD MALVGAVSVL VDPAATDAAS KLGVLSPDFR
CATFDKDANG YVRAEGVGCV VVKRLADAQR DGDAVLAVLE AVAENHDGRS NSLTAPNPEA
QVALLTKVYT PELADRVSHI EAHGTGTNLG DPIEISALRT AFGRLAPHRE PGAITLGAVK
TNVGHLEPAA GMAGLLKLLL CLRHRRLPAN INFKQLNPLV ELDGSPFRLL LENEPWQRAV
PLVAGVSSFG FGGSNAHAVL SEAPAPQPAP RAPRAHWLIT LSARSRASLA TMREELLEWL
GGPEAERADL ADIAHTLAAG RDHFEYRQAW IVSSTEELRE RLTQARSQEP VKCRPQRLTT
HPVRLPDPAD PAHRAALEDL GARYVQGEEF AWETMFGDGQ FSRLHLPGYA FEQNRFWFE
//
