ID A0A101NUL6_9ACTN Unreviewed; 625 AA.
AC A0A101NUL6;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (Decyclizing) {ECO:0000313|EMBL:KUM99658.1};
GN ORFNames=AQI95_37435 {ECO:0000313|EMBL:KUM99658.1};
OS Streptomyces yokosukanensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=67386 {ECO:0000313|EMBL:KUM99658.1, ECO:0000313|Proteomes:UP000053127};
RN [1] {ECO:0000313|EMBL:KUM99658.1, ECO:0000313|Proteomes:UP000053127}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40224 {ECO:0000313|EMBL:KUM99658.1,
RC ECO:0000313|Proteomes:UP000053127};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces yokosukanensis DSM 40224, type
RT strain for the species Streptomyces yokosukanensis.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUM99658.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LMWN01000061; KUM99658.1; -; Genomic_DNA.
DR RefSeq; WP_067134786.1; NZ_KQ948227.1.
DR AlphaFoldDB; A0A101NUL6; -.
DR STRING; 67386.AQI95_37435; -.
DR OrthoDB; 3194735at2; -.
DR Proteomes; UP000053127; Unassembled WGS sequence.
DR GO; GO:0016823; F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0019310; P:inositol catabolic process; IEA:InterPro.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR030817; Myo_inos_IolD.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR NCBIfam; TIGR04377; myo_inos_iolD; 1.
DR PANTHER; PTHR18968:SF9; 3D-(3,5/4)-TRIHYDROXYCYCLOHEXANE-1,2-DIONE HYDROLASE; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:KUM99658.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053127};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 6..125
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 219..351
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 418..575
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 625 AA; 67205 MW; 94B91813452374BE CRC64;
MTIRLTVAQA LVRFLAAQYT ERDGERQRLI GATWGIFGHG NVAGLGQALV EYAEVMPYHQ
GRNEQSMVHA AVGYARQAGR LSTHAVTTSI GPGATNLVTG AALATINHLP VLLLPGDVFA
TRPADPVLQQ LEVPYAGDVS VNDTLRPVSR YFDRVTRPEA LIPSALQAMR VLADPVETGA
VTLALPQDVQ AEAFDWPEEF FADRVWAIRR PGADPTELAE AVRAIRDARR PLVIAGGGVH
HSRAEAALAE FAEATRIPVA STQAGKGSLR HDHPQDVGGV GHTGTATADE LARTADLVIG
VGTRYTDFTT ASGTLFENPD VRFLNLNIAP FDGHKLSGLP LVADARSGLG ELTEALVLHG
HRVPEPYARE YTEDKERWEQ RVDACFEADE IDVRPTQPQV IGALDALVDE SDIIVGAAGS
LPGDLHKLWR ARSCDQYHLE YGYSCMGYEI PAALGVKLAA PHRNVWALVG DGTYLMMPTE
IVTAVQEGIA IKVLLVQNHG YASIGGLSES VGGERFGTAY RFQAGDGTYT GAPLPVDLAA
NAASLGMRVL RAKTVRDLRA ALAEARAADT PTCVYVETET SDTVSGAPPA QAWWDVPVAE
TATRPSAVKA RELYERHVST RRRHL
//