ID A0A101NXH1_9ACTN Unreviewed; 803 AA.
AC A0A101NXH1;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Peptidase M4 {ECO:0000313|EMBL:KUN01125.1};
GN ORFNames=AQI95_32115 {ECO:0000313|EMBL:KUN01125.1};
OS Streptomyces yokosukanensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=67386 {ECO:0000313|EMBL:KUN01125.1, ECO:0000313|Proteomes:UP000053127};
RN [1] {ECO:0000313|EMBL:KUN01125.1, ECO:0000313|Proteomes:UP000053127}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40224 {ECO:0000313|EMBL:KUN01125.1,
RC ECO:0000313|Proteomes:UP000053127};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces yokosukanensis DSM 40224, type
RT strain for the species Streptomyces yokosukanensis.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M4 family.
CC {ECO:0000256|ARBA:ARBA00009388}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUN01125.1}.
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DR EMBL; LMWN01000044; KUN01125.1; -; Genomic_DNA.
DR RefSeq; WP_067131969.1; NZ_KQ948220.1.
DR AlphaFoldDB; A0A101NXH1; -.
DR STRING; 67386.AQI95_32115; -.
DR OrthoDB; 291295at2; -.
DR Proteomes; UP000053127; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProt.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd09597; M4_TLP; 1.
DR Gene3D; 3.10.170.10; -; 1.
DR Gene3D; 3.10.450.490; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR011096; FTP_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR023612; Peptidase_M4.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR InterPro; IPR001570; Peptidase_M4_C_domain.
DR InterPro; IPR013856; Peptidase_M4_domain.
DR PANTHER; PTHR33794; BACILLOLYSIN; 1.
DR PANTHER; PTHR33794:SF1; BACILLOLYSIN; 1.
DR Pfam; PF07504; FTP; 1.
DR Pfam; PF05345; He_PIG; 1.
DR Pfam; PF01447; Peptidase_M4; 1.
DR Pfam; PF02868; Peptidase_M4_C; 1.
DR PRINTS; PR00730; THERMOLYSIN.
DR SUPFAM; SSF49313; Cadherin-like; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000053127};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..803
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007102044"
FT DOMAIN 87..123
FT /note="FTP"
FT /evidence="ECO:0000259|Pfam:PF07504"
FT DOMAIN 229..376
FT /note="Peptidase M4"
FT /evidence="ECO:0000259|Pfam:PF01447"
FT DOMAIN 379..553
FT /note="Peptidase M4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02868"
FT ACT_SITE 369
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
FT ACT_SITE 456
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
SQ SEQUENCE 803 AA; 82332 MW; 86ABE47AC2936C08 CRC64;
MPHRPGSRTG RTRTTVGVAL LSTAAFLAVG LQAAPAIATP AAAHPGSLRT GGMEAKLSPA
QHQALMKSAR QQTDATARTL GLGAKEKLVV KDVVKDNDGT LHTRYERTYA GLPVLGGDLV
VHTPPASLAK GTVTTTYNNK HTIKVASTTA TITRSAAEST ALKAAKSLAA KKPTTDSARK
VIWAGSGTPR LAWETVIGGF QDDGTPSQLH VVTDAGTGKE LYRYQAVKTG TGNTRYSGQV
NLTTTQSGST YTLTDGARGG HKTYNLNHGS SGTGTLFSQN NDTWGDGTNT NAATAGADAH
YGAQETWDFY KNTFGRSGIK NDGVGAYSRV HYGNSYVNAF WDDSCFCMTY GDGSGNNDPL
TAIDVAGHEM SHGVTSNTAG LEYTGESGGL NEATSDIMGT GVEFYANNSS DPGDYLIGEK
ININGDGTPL RYMDKPSKDG GSADSWYSGV GGLDVHYSSG PANHMFYLLS EGSGTKVING
VTYNSPTSDG VAVTGIGRAA ALQIWYKALT TYMTSSTDYA AARTAALNAA TALYGANSAQ
YAGVANAFAG INVGSHVTPP GNGVTVTNPG NQTSTVGTAV SLQVQASSTN SGALSYSASG
LPAGLSINSS TGLITGTPTT AGTSNTTVTV TDSTGATGTA TFSWTVNSSG GGGCTSTQLL
ANPGFESGGT GWTATSGVIT NDTGEAAHGG SYKAWLDGYG SSHTDTLSQS VTIPAGCKAT
LTYYLHIDSA ETTTSTQYDK LTVTAGSKTL ATYSNLNKAS GYSQKSFDLS SLAGSTVTLK
FNGVEDSSLQ TSFVVDDTAL TTG
//
