ID A0A101NZ21_9ACTN Unreviewed; 655 AA.
AC A0A101NZ21;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Acetoacetyl-CoA synthetase {ECO:0000313|EMBL:KUN01893.1};
DE EC=6.2.1.16 {ECO:0000313|EMBL:KUN01893.1};
GN ORFNames=AQI95_27715 {ECO:0000313|EMBL:KUN01893.1};
OS Streptomyces yokosukanensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=67386 {ECO:0000313|EMBL:KUN01893.1, ECO:0000313|Proteomes:UP000053127};
RN [1] {ECO:0000313|EMBL:KUN01893.1, ECO:0000313|Proteomes:UP000053127}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40224 {ECO:0000313|EMBL:KUN01893.1,
RC ECO:0000313|Proteomes:UP000053127};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces yokosukanensis DSM 40224, type
RT strain for the species Streptomyces yokosukanensis.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUN01893.1}.
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DR EMBL; LMWN01000040; KUN01893.1; -; Genomic_DNA.
DR RefSeq; WP_067129523.1; NZ_KQ948217.1.
DR AlphaFoldDB; A0A101NZ21; -.
DR STRING; 67386.AQI95_27715; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000053127; Unassembled WGS sequence.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd05943; AACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:KUN01893.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053127}.
FT DOMAIN 41..97
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 100..472
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 539..614
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 655 AA; 72002 MW; 602EEE810AACB046 CRC64;
MSTANPQPLW QPDPQRIAQA RITQFQAWAA EHHGAPAEGG YSALHLWSVD QLDTFWKALA
EFFDVRFSTP YARVLGDRSM PGAQWFPGAT LNYAEHALRA AADRADLPAL LHVDETQEPR
PVTWAELRRQ VGSLAAELRA LGVRPGDRVS GYLPNIPQAV VALLATAAVG AVWTSCAPDF
GARSVLDRFQ QVEPVVLFTV DGYRYGGKEH DRRDIVAELR RELPTVRAVV HIPLLGTEAP
EGALQWSALT AGDTEPVFEQ VPFDHPLWVL YSSGTTGLPK AIVQSQGGIL VEHLKQLGLH
CDLGPEDRFF WYTSTGWMMW NFLVSGLLTG TTIVLYDGSP GYPDTGAQWR VAERTGATLY
GTSAAYVMAC RKAGVHPARD YDLTAMKCVA TTGSPLPPDG FRWLHDEVRD DLWIASVSGG
TDVCSCLAGG VPTLPVYTGE LQAPGLGTDL QAWDPGGRPV VDEVGELVVT EPMPSMPIRF
WNDPDGSRYH DSYFDTYPGV WRHGDWITVT SRGTVIIHGR SDSTLNRQGV RMGSADIYEV
VERLPEIRES LVIGIEQPDG GYWMPLFVHL APGAVLDEAL LNRIKQAIRE QLSPRHVPDE
VIEVPGVPHT LTGKRIEVPV KRLLQGTPLE KAVNPGSIDN LALLDFYEEL ARKRG
//
