ID   A0A101P508_9ACTN        Unreviewed;       358 AA.
AC   A0A101P508;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Zn-dependent alcohol dehydrogenase {ECO:0000313|EMBL:KUN05058.1};
GN   ORFNames=AQI95_16255 {ECO:0000313|EMBL:KUN05058.1};
OS   Streptomyces yokosukanensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=67386 {ECO:0000313|EMBL:KUN05058.1, ECO:0000313|Proteomes:UP000053127};
RN   [1] {ECO:0000313|EMBL:KUN05058.1, ECO:0000313|Proteomes:UP000053127}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40224 {ECO:0000313|EMBL:KUN05058.1,
RC   ECO:0000313|Proteomes:UP000053127};
RA   Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT   "Draft genome sequence of Streptomyces yokosukanensis DSM 40224, type
RT   strain for the species Streptomyces yokosukanensis.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUN05058.1}.
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DR   EMBL; LMWN01000021; KUN05058.1; -; Genomic_DNA.
DR   RefSeq; WP_067123488.1; NZ_KQ948211.1.
DR   AlphaFoldDB; A0A101P508; -.
DR   STRING; 67386.AQI95_16255; -.
DR   OrthoDB; 334894at2; -.
DR   Proteomes; UP000053127; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08279; Zn_ADH_class_III; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR43880; ALCOHOL DEHYDROGENASE; 1.
DR   PANTHER; PTHR43880:SF12; ALCOHOL DEHYDROGENASE CLASS-3; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053127};
KW   Zinc {ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          10..352
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   358 AA;  37266 MW;  1ED8BBE9368BC104 CRC64;
     MRAAVLHEIG QEKLEVLDDV EAVGFGPGKV RVRVRATGLC HSDLSAMSGV LPQPAPFVPG
     HEGAGEILEV GDGVRGLRPG DRVVLCWLPA CGACPACKRG QTQLCLAGFM NAGTPNFKRA
     SGDVFGFAGT GTFAEEVVVD AGCAVPIPED VPFDIAALIG CGVTTGLGAA LNTADVEAGS
     SVAVIGCGGV GISAVQGARL KGAAEIVAVD PVASRRESAL KFGATKAVSP DELAEAKQQV
     TGGEGFDYVF EVVGRSATAR TAYENTRRGG TLVVVGAGAM DDFLQLNMFE LFFDEKRILP
     SMYGGGDVLR SYERAIALWQ AGRIDLAGLI THRVRLSEIN EALDQMRTGT ALRTCIEI
//