ID A0A101P9U3_9ACTN Unreviewed; 547 AA.
AC A0A101P9U3;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=AQI95_10710 {ECO:0000313|EMBL:KUN07551.1};
OS Streptomyces yokosukanensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=67386 {ECO:0000313|EMBL:KUN07551.1, ECO:0000313|Proteomes:UP000053127};
RN [1] {ECO:0000313|EMBL:KUN07551.1, ECO:0000313|Proteomes:UP000053127}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40224 {ECO:0000313|EMBL:KUN07551.1,
RC ECO:0000313|Proteomes:UP000053127};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces yokosukanensis DSM 40224, type
RT strain for the species Streptomyces yokosukanensis.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUN07551.1}.
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DR EMBL; LMWN01000012; KUN07551.1; -; Genomic_DNA.
DR RefSeq; WP_067121531.1; NZ_KQ948209.1.
DR AlphaFoldDB; A0A101P9U3; -.
DR STRING; 67386.AQI95_10710; -.
DR OrthoDB; 3713880at2; -.
DR Proteomes; UP000053127; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd18029; DEXHc_XPB; 1.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:KUN07551.1};
KW Helicase {ECO:0000313|EMBL:KUN07551.1};
KW Hydrolase {ECO:0000313|EMBL:KUN07551.1};
KW Nucleotide-binding {ECO:0000313|EMBL:KUN07551.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053127}.
FT DOMAIN 189..343
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 397..545
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 547 AA; 61005 MW; 3BF422C49CF995F1 CRC64;
MNGPLIVQSD KTLLLEVDHE RADECRRAIA PFAELERAPE HIHTYRVTPL GLWNARAAGH
DAEQVVDALV QYSRYPVPHA LLVDIAETMD RYGRLTLSKH PAHGLVLSTT DRPVLEEVLK
SKRIAPLVGA RIDPDTVVVH PSERGQIKQT LLKLGWPAED LAGYVDGEAH PIELLEDGWA
LRPYQKQAVE NFWHGGSGVV VLPCGAGKTL VGAGSMAQAK STTLILVTNT VSARQWKHEL
VKRTSLTEDE IGEYSGTRKE IRPVTIATYQ VLTTKRKGVY PHLELFDSRD WGLIVYDEVH
LLPAPVFKFT ADLQARRRLG LTATLVREDG RESDVFSLIG PKRFDAPWKE IEAQGYIAPA
DCVEVRVNLT DSERLAYATA ETEEKYRFCA TTDTKRKVTE AIVRRFAGQQ ILVIGQYIDQ
LDELGEHLNA PVIKGETSNA QREKLFDAFR EGEISVLVVS KVANFSIDLP EATVAVQVSG
TFGSRQEEAQ RLGRVLRPKA DGHQAHFYSV VARDTIDQDF AAHRQRFLAE QGYAYRIVDA
DELLAEG
//
