ID   A0A101RX99_9ACTN        Unreviewed;       314 AA.
AC   A0A101RX99;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=5'-3' exonuclease {ECO:0000313|EMBL:KUN63426.1};
GN   ORFNames=AQJ54_27045 {ECO:0000313|EMBL:KUN63426.1};
OS   Streptomyces griseorubiginosus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=67304 {ECO:0000313|EMBL:KUN63426.1, ECO:0000313|Proteomes:UP000054375};
RN   [1] {ECO:0000313|EMBL:KUN63426.1, ECO:0000313|Proteomes:UP000054375}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40469 {ECO:0000313|EMBL:KUN63426.1,
RC   ECO:0000313|Proteomes:UP000054375};
RA   Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT   "Draft genome sequence of Streptomyces griseorubiginosus DSM 40469, type
RT   strain for the species Streptomyces griseorubiginosus.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUN63426.1}.
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DR   EMBL; LMWV01000022; KUN63426.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A101RX99; -.
DR   OrthoDB; 9806424at2; -.
DR   Proteomes; UP000054375; Unassembled WGS sequence.
DR   GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro.
DR   CDD; cd09898; H3TH_53EXO; 1.
DR   CDD; cd09859; PIN_53EXO; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR   InterPro; IPR002421; 5-3_exonuclease.
DR   InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR   InterPro; IPR020045; DNA_polI_H3TH.
DR   InterPro; IPR038969; FEN.
DR   InterPro; IPR008918; HhH2.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   PANTHER; PTHR42646:SF2; DNA-DIRECTED DNA POLYMERASE; 1.
DR   PANTHER; PTHR42646; FLAP ENDONUCLEASE XNI; 1.
DR   Pfam; PF01367; 5_3_exonuc; 1.
DR   Pfam; PF02739; 5_3_exonuc_N; 1.
DR   SMART; SM00475; 53EXOc; 1.
DR   SMART; SM00279; HhH2; 1.
DR   SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Exonuclease {ECO:0000313|EMBL:KUN63426.1};
KW   Hydrolase {ECO:0000313|EMBL:KUN63426.1};
KW   Nuclease {ECO:0000313|EMBL:KUN63426.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054375}.
FT   DOMAIN          11..285
FT                   /note="5'-3' exonuclease"
FT                   /evidence="ECO:0000259|SMART:SM00475"
SQ   SEQUENCE   314 AA;  34003 MW;  BC25BE4CCB6F6923 CRC64;
     MPYGMMRGVT GRLMLLDTAS LYFRAYFGVP ESVKAPDGTP VNAVRGLLEF IDRLVKDHHP
     DALVACMDAD WRPQWRVDLI PSYKAHRVAE EHEVGPDEEE VPDTLSPQVP IIEAVLDALG
     IARVGVAGYE ADDVIGTFTA LAKGPVDIVT GDRDLYQLVD DEREVRVLYP LKGVGTLQLT
     DETWLREKYG VDGRGYADLA LLRGDPSDGL PGVPGIGEKT AAKLLAEFGD LAGIMAAVED
     PKAKLTPSQR KRLDESRPYV AVAPKVVRVA GDVPLPQVET ALPRAPRDPE MLDALGTRWG
     LGGSLHRLVA TLGA
//