ID   A0A101S218_9ACTN        Unreviewed;       469 AA.
AC   A0A101S218;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Metallopeptidase {ECO:0000313|EMBL:KUN65992.1};
GN   ORFNames=AQJ54_20110 {ECO:0000313|EMBL:KUN65992.1};
OS   Streptomyces griseorubiginosus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=67304 {ECO:0000313|EMBL:KUN65992.1, ECO:0000313|Proteomes:UP000054375};
RN   [1] {ECO:0000313|EMBL:KUN65992.1, ECO:0000313|Proteomes:UP000054375}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40469 {ECO:0000313|EMBL:KUN65992.1,
RC   ECO:0000313|Proteomes:UP000054375};
RA   Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT   "Draft genome sequence of Streptomyces griseorubiginosus DSM 40469, type
RT   strain for the species Streptomyces griseorubiginosus.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUN65992.1}.
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DR   EMBL; LMWV01000016; KUN65992.1; -; Genomic_DNA.
DR   RefSeq; WP_062239244.1; NZ_KQ948737.1.
DR   AlphaFoldDB; A0A101S218; -.
DR   Proteomes; UP000054375; Unassembled WGS sequence.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd09603; M1_APN_like; 1.
DR   Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR   Gene3D; 2.60.40.1730; tricorn interacting facor f3 domain; 1.
DR   InterPro; IPR045357; Aminopeptidase_N-like_N.
DR   InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR   InterPro; IPR014782; Peptidase_M1_dom.
DR   InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR   PANTHER; PTHR11533:SF303; AMINOPEPTIDASE N; 1.
DR   PANTHER; PTHR11533; PROTEASE M1 ZINC METALLOPROTEASE; 1.
DR   Pfam; PF01433; Peptidase_M1; 1.
DR   Pfam; PF17900; Peptidase_M1_N; 1.
DR   SUPFAM; SSF63737; Leukotriene A4 hydrolase N-terminal domain; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000054375};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..469
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5007105629"
FT   DOMAIN          49..215
FT                   /note="Aminopeptidase N-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17900"
FT   DOMAIN          307..446
FT                   /note="Peptidase M1 membrane alanine aminopeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF01433"
SQ   SEQUENCE   469 AA;  51330 MW;  5DA679EFBFBF4A13 CRC64;
     MRRLAAPPLA ALALCVLTGL APASAADGGP GLGDPYFPTD GNSGYDVDRY DVRIAYDPAR
     PDHLTGDTTV TARALTDLGR FHLDLTGFDV SSVTVDGRTA RSVEREGENE LVITPARELR
     KGADFSVRVR YSGKPVGEGW HPMADGGVAI SGEPHSATTW YPANDHPSDK ATFRLTATVP
     DGWSAVGNGR PGRVTRDGTG RRTFRWYEDR PLTTYASMVA VGRFTVRSSE LPDGTPVVNA
     YSPDALIDPD AEALQEDILG FLASRFGPYP FSSAGAVVLA GPSGTGPVDL ETQSRPTYDT
     GLFDVAMVHE LAHQWYGDSV SFTDWRDGCV AECVATYAQW LWYEHQGDDL DRDYYLATVK
     EHRTDPAFWS VPLYDPGAGR ELDSALYARG PLMLHALRRT VGDQAFFDIL RTWPARHRYG
     NASWPEFETL AAERSHRDLR GFFTAWAHGT QIPPDRYLLP EGLSRAATG
//