ID A0A101S3L3_9ACTN Unreviewed; 598 AA.
AC A0A101S3L3;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Thiamine pyrophosphate-binding protein {ECO:0000313|EMBL:KUN66623.1};
GN ORFNames=AQJ54_15450 {ECO:0000313|EMBL:KUN66623.1};
OS Streptomyces griseorubiginosus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=67304 {ECO:0000313|EMBL:KUN66623.1, ECO:0000313|Proteomes:UP000054375};
RN [1] {ECO:0000313|EMBL:KUN66623.1, ECO:0000313|Proteomes:UP000054375}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40469 {ECO:0000313|EMBL:KUN66623.1,
RC ECO:0000313|Proteomes:UP000054375};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces griseorubiginosus DSM 40469, type
RT strain for the species Streptomyces griseorubiginosus.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUN66623.1}.
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DR EMBL; LMWV01000014; KUN66623.1; -; Genomic_DNA.
DR RefSeq; WP_062237845.1; NZ_KQ948736.1.
DR AlphaFoldDB; A0A101S3L3; -.
DR Proteomes; UP000054375; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd02014; TPP_POX; 1.
DR CDD; cd07039; TPP_PYR_POX; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR047211; POXB-like.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR InterPro; IPR047212; TPP_POXB-like.
DR InterPro; IPR047210; TPP_PYR_POXB-like.
DR PANTHER; PTHR42981; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR PANTHER; PTHR42981:SF2; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000054375};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 4..118
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 198..328
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 389..544
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 598 AA; 65424 MW; 7E1856A6B99AD6EC CRC64;
MSTKVSDHIL ERLREWGVDH VFGYPGDGIN GLLAAWGRAD NQPRFVQSRH EEMSAFEAVG
YAKFSGRIGV CAATSGPGAI HLLNGLYDAK LDHVPVLAIV GQTHRTAMGG SYQQEVDLHT
LFKDVASEFV ETVTVPEQLP NVLDRAIRTA YARRCPTAII IPGDVQELDY APPTHEFKML
PSSLGRSNWT TVPSEESLQR AAEILNSGEK PAILIGQGAA GARAEVERVA EMLGAGVAKA
LLGKDVLSDE LPYVTGSIGL LGTRPSYELM RDCDTLLTIG SSFPYTQFMP EFGKARAVQI
DIDPHMIGMR YPYEVNLVGD AKATLQRLIP MLDAERGERK WYETVCDNVK RWRDVMDRRA
QQSADPINPE YVARALDPLL PDDVIVTSDS GSTANWYARH LTMRPGMRSS LSGTLATMGP
GVPYAIGAKF AHPDRPAIAL VGDGAMQMNG MAELITAAKY RELWEDPRLI IAVWNNHDLN
QVTWEMRAME GAPSFLPSQQ LPDVQYAAFA RSLGLTGIRV EKPEDVEAAW RAGLAADGPA
VLEFLTDPAV PPIPPHATWE QMEATAAAIL KGDADRGSMV KQGFKAKVQE FLPGREKK
//
