ID   A0A101S8R4_9ACTN        Unreviewed;       785 AA.
AC   A0A101S8R4;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Peptidase M4 {ECO:0000313|EMBL:KUN69639.1};
GN   ORFNames=AQJ54_08370 {ECO:0000313|EMBL:KUN69639.1};
OS   Streptomyces griseorubiginosus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=67304 {ECO:0000313|EMBL:KUN69639.1, ECO:0000313|Proteomes:UP000054375};
RN   [1] {ECO:0000313|EMBL:KUN69639.1, ECO:0000313|Proteomes:UP000054375}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40469 {ECO:0000313|EMBL:KUN69639.1,
RC   ECO:0000313|Proteomes:UP000054375};
RA   Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT   "Draft genome sequence of Streptomyces griseorubiginosus DSM 40469, type
RT   strain for the species Streptomyces griseorubiginosus.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M4 family.
CC       {ECO:0000256|ARBA:ARBA00009388}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUN69639.1}.
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DR   EMBL; LMWV01000005; KUN69639.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A101S8R4; -.
DR   Proteomes; UP000054375; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProt.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd09597; M4_TLP; 1.
DR   Gene3D; 3.10.170.10; -; 1.
DR   Gene3D; 3.10.450.40; -; 1.
DR   Gene3D; 3.10.450.490; -; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR011096; FTP_domain.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR023612; Peptidase_M4.
DR   InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR   InterPro; IPR001570; Peptidase_M4_C_domain.
DR   InterPro; IPR013856; Peptidase_M4_domain.
DR   PANTHER; PTHR33794; BACILLOLYSIN; 1.
DR   PANTHER; PTHR33794:SF1; BACILLOLYSIN; 1.
DR   Pfam; PF07504; FTP; 1.
DR   Pfam; PF05345; He_PIG; 1.
DR   Pfam; PF01447; Peptidase_M4; 1.
DR   Pfam; PF02868; Peptidase_M4_C; 1.
DR   PRINTS; PR00730; THERMOLYSIN.
DR   SUPFAM; SSF49313; Cadherin-like; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054375};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          67..103
FT                   /note="FTP"
FT                   /evidence="ECO:0000259|Pfam:PF07504"
FT   DOMAIN          210..357
FT                   /note="Peptidase M4"
FT                   /evidence="ECO:0000259|Pfam:PF01447"
FT   DOMAIN          360..534
FT                   /note="Peptidase M4 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02868"
FT   ACT_SITE        350
FT                   /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
FT   ACT_SITE        437
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
SQ   SEQUENCE   785 AA;  80058 MW;  C4C87F8CF62F7EFD CRC64;
     MAAASLLAVG VQTVPAAAGP ASPHPSPLRT GGLEAKLSPA QRTALIKSAS GKAEATADSL
     GLGAKEKLVV KDVVKDNDGT LHTRYERTYD GVPVLGGDLV VHTPPASLAA GTVSTTFNNN
     RRTVSVKSTT ATFSKAAAQT KALRTAKALK AENPAAQSAR KVIWAGSGTP KLAWETVVSG
     FQDDGTPSKL HVITDATTGA ELSRYEGVET GTGNSQYSGT VPLSTTLSGS TYQLYDTTRG
     GHKTYSLNNG TSGTGTLMTD ADDTWGTGSG SNTQTAGVDA HYGAQETWDF YKNTFGRSGI
     KNDGVAAYSR VHYSSSYVNA FWDDDCFCMT YGDGSGGTHA LTSLDVAGHE MSHGVTSNTA
     GLNYTGESGG LNEATSDIFG TGVEFYANNS TDVGDYLIGE KIDINGNGTP LRYMDKPSKD
     GSSADSWYSG VGNLDVHYSS GPANHMFYLL SEGSGTKTIN GVTYTSTTSD GVAVAGIGRA
     AALQIWYKAL TTYMTSSTTY AGARTAALNA AAALYGTSST QYAGVGNAFA GINVGSHITV
     PSTGVTVTNP GSQTSTVGTA VSLQISASST NSGSLSYAAT GLPAGLSISS STGAITGTPT
     TAGTSSTTVT VTDSTGATGT ASFTWTVNAA GGGSCTSTQL LGNQGFESGN TTWTASSGVI
     TNASGEAART GSYKAWLDGY GSTHTDTLSQ SVTVPSGCTG TTFTFYLHID TAETTTSTQY
     DKLTVTAGST TLATYSNLNA ASGYVQKSFS LAAFAGQTVT LKFTGVEDSS LQTSFVIDDT
     AVTTS
//