ID A0A101SJG1_9ACTN Unreviewed; 575 AA.
AC A0A101SJG1;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Radical SAM protein {ECO:0000313|EMBL:KUN75130.1};
GN ORFNames=AQJ64_43635 {ECO:0000313|EMBL:KUN75130.1};
OS Streptomyces griseoruber.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1943 {ECO:0000313|EMBL:KUN75130.1, ECO:0000313|Proteomes:UP000052982};
RN [1] {ECO:0000313|EMBL:KUN75130.1, ECO:0000313|Proteomes:UP000052982}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40281 {ECO:0000313|EMBL:KUN75130.1,
RC ECO:0000313|Proteomes:UP000052982};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces griseoruber DSM 40281, type strain
RT for the species Streptomyces griseoruber.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUN75130.1}.
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DR EMBL; LMWW01000090; KUN75130.1; -; Genomic_DNA.
DR RefSeq; WP_055633933.1; NZ_LIQS01000157.1.
DR AlphaFoldDB; A0A101SJG1; -.
DR STRING; 1943.AQJ64_43635; -.
DR OrthoDB; 5298546at2; -.
DR Proteomes; UP000052982; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR PANTHER; PTHR43409:SF7; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE; 1.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SFLD; SFLDF00418; pactamycin_C-methyltransferase; 1.
DR SFLD; SFLDF00438; pactamycin_methyltransferase; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 31..168
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 210..451
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 575 AA; 64502 MW; E4651C80967349BA CRC64;
MADAVLMTPR EILTGFSSVN NQNVLINDDE YLRLDPAMRL FYEKVRENLG VACIAGHLRS
CGYAVRALNL HGRNPSDEAI TDLIRRERPM FVGISIMYDL HIVDAVRLLR CVREADPSVF
VAIGGAFCTY NAKLIAERIP EADCVAFGEG ELTVEGLMEC LAAGRDWRGV PGLWFWRDGR
VRSSGSPRLP DLAKEAWPAR DLLVHHRGNR IPTPVASTYT SRGCHAKCTF CYVPRAPGVT
AGNAWRVRSP VDVVDEIEFL QREFGTRFLW FNDDNFGGAF QDGYSHAVGF AEEILRRDLK
ISFHCEFRVD TGLVDREALR TLRRAGMASA LLGMETGAPS MAKRFRKGTM VEYNLDAARL
FKQEGIELEP GWIMVEPGTT LDELWENLKF IVAADIAVSE NPFSFISRAI ALRGTEMYDR
IADPTPPELP DVEGPARAVL LEARREYRIP DRRVEDVWAA WSKVSAEVAD RKEELPFVAQ
LIVDATRARR TRGEPGLRPL LSRLRGWADG LAELLVAFLN LGLLLADENP PRLAERLETE
LRALVDAYDR RVLGDPYPVF VARIRRLCGE QAMAG
//