ID A0A101TNC2_9ACTN Unreviewed; 1179 AA.
AC A0A101TNC2;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Transcriptional regulator {ECO:0000313|EMBL:KUN95512.1};
GN ORFNames=AQJ67_34865 {ECO:0000313|EMBL:KUN95512.1};
OS Streptomyces caeruleatus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=661399 {ECO:0000313|EMBL:KUN95512.1, ECO:0000313|Proteomes:UP000053429};
RN [1] {ECO:0000313|EMBL:KUN95512.1, ECO:0000313|Proteomes:UP000053429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-24802 {ECO:0000313|EMBL:KUN95512.1,
RC ECO:0000313|Proteomes:UP000053429};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces caeruleatus NRRL B-24802, type
RT strain for the species Streptomyces caeruleatus.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUN95512.1}.
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DR EMBL; LMWY01000048; KUN95512.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A101TNC2; -.
DR STRING; 661399.AQJ67_34865; -.
DR Proteomes; UP000053429; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR35807:SF1; TRANSCRIPTIONAL REGULATOR REDD; 1.
DR PANTHER; PTHR35807; TRANSCRIPTIONAL REGULATOR REDD-RELATED; 1.
DR Pfam; PF03704; BTAD; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF13374; TPR_10; 1.
DR Pfam; PF13424; TPR_12; 1.
DR Pfam; PF13181; TPR_8; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00028; TPR; 5.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU01091}; Reference proteome {ECO:0000313|Proteomes:UP000053429};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 1..102
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DNA_BIND 1..102
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
FT REGION 259..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..601
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 777..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 857..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..340
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..383
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..427
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..792
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1179 AA; 125836 MW; EB330EEA01D6B3EA CRC64;
MRFGLLGPPV VFEDAPEEAS SYDAQDLPVR MISSPKVRAL FAALLLEGGR VVSVESLKDV
LWGGAPPASA QASLHNHVAR LRRLLDRPER LRAVPPGYVL RVDEGELDVD VFVSRVAAAR
VAHAGRDWER TVRECTRALA LWRGTPLAGL PAEVGGYALV QRLAEARLLL LEWRYDAELN
IAGPGLDALV PELTALAAEH PLRESFHRHL MLALHHTGRR AEALTVHRVL RTRLIEELGV
EPGAGVREAH VEVLRGGEGA GRGWGGGAAG PAGPADGPAR AGVHHDLRTA TQGPAEHGGA
LVPGASDAAA GPEADLPDAP ANLDATRDDD PLHRPHPAPS VRETHMSAAP APRDPDASTT
TPPTPPRVTP TDPPRPAQLP PPPAHFTGRT AVLHDLRRTL TPTPTPTPTS TPTPTSTPSP
TSAPTPAPAR QRPHTAVAVI SGMAGVGKSA LALEAAHGLA NRFPDGQLHV NLHGATPGMP
PLTSGQALTA LLRDLGTDPR AIPEHPDAAA ALLRSLLAPT RTLVVLDDAA NAAQVRPLLP
AAPGCAVIVT SRSPLTALDG VHRFPLTPLP AEDSAALLRA ASGRGARDGH DTAERAPDGT
TAPIDAVHPL VALTGGLPLA LRVVAARLAA RSALTPEVLA RQLAATESRL HHLEYDDLSV
RRSLAVAHDA LAASDREADR DAALALRRIG ALDLPAYGAP LLARLTGTDE RRAEAALDRL
VDVALLEETA YGRYTPHDLV RDFARELAES DGDFTGTAET ALRWYAAAAE RTLTAIVEPG
LDRDDRRRPT PTQPQDHATT VDTVAAFDSP EAAFAWADLE LENIVALAER HGGADHDEQD
SPTVPHATVP HAITTHTTVP HTTTPHTTTP HTTTPHNPAA PLLSTLIRLL FPYLQRSGRV
AEMELLGGAG LRVARRLGDE AAEAYALGDL AGLHFLTGRQ SEALHLNDRA LAIWRRLEVV
SWTRRCLNNR GLLLEGLGRY AESGEALRQS LEYSRQLNDP HGEAVTYSHL GNLYEHTDPR
AAIEQHRRSL AIGDEIGNVI VQHSAHCNIG YAHLTLGEPA AAATHFEESL RILGGHGDWH
GESQTRLGLV RALRLLGRTE PATHALAELL TRADARADRY TGGLARHQKG LLLHERGRVQ
EAHAEWRTAL DLLDGTDEKA VVEELRQLLP DPATDAVRR
//
