ID   A0A101TND0_9ACTN        Unreviewed;       740 AA.
AC   A0A101TND0;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=MMPL domain-containing protein {ECO:0000313|EMBL:KUN95509.1};
GN   ORFNames=AQJ67_34790 {ECO:0000313|EMBL:KUN95509.1};
OS   Streptomyces caeruleatus.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=661399 {ECO:0000313|EMBL:KUN95509.1, ECO:0000313|Proteomes:UP000053429};
RN   [1] {ECO:0000313|EMBL:KUN95509.1, ECO:0000313|Proteomes:UP000053429}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL B-24802 {ECO:0000313|EMBL:KUN95509.1,
RC   ECO:0000313|Proteomes:UP000053429};
RA   Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT   "Draft genome sequence of Streptomyces caeruleatus NRRL B-24802, type
RT   strain for the species Streptomyces caeruleatus.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUN95509.1}.
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DR   EMBL; LMWY01000048; KUN95509.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A101TND0; -.
DR   STRING; 661399.AQJ67_34790; -.
DR   Proteomes; UP000053429; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053429};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        190..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        235..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        309..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        373..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        534..553
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        560..581
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        601..622
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        643..670
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        676..702
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          83..372
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   DOMAIN          403..730
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   REGION          718..740
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   740 AA;  77622 MW;  E73FB2C32B1542EE CRC64;
     MERIAGWSIR HRALAIGGWL GLVVVALLAS AVLSGSSAST DDPGESGAVK RVLREQKNYE
     PILENVLIQP REDGGGKFMD DPALVKATED LVAEFDKLPG AVADLRTPLK PGSEQQISKD
     GRSGLVTFFV AGPNDKMTAH FDSVVAAVDK VADQNKDVRV VQAGDVSLSR AVDDAVKKDF
     ASAERTSLPI TLVILLVVFG ALVAAAIPLL LAATTVVATF SLIAVVERWV AVNSAVTSMI
     LLIGIAVSVD YSLFYLRRER EERAAGRSVA ESLHIASRTS GHVVIVSGVT VILCLSGLLL
     SGLDVFRGLT LGTALVVGLA MIASVTVLPA LLAALGHRVD KGRVPWLGKR RTTVAESRGW
     QKLARAVVNR PKVWGGAAVL ALLVMAAPAL DMRLQDAAVV NSLPRSAPTV DAAIRMQEAF
     PGSPTPAKVA VWGVDGGSSD TPEVKAAVDR LHQQIADSDG RLAGPISTVR VDDVLMVRVP
     LAGSGTDEVS NEALATLRDV ALPATLGKVE GIDYAVAGRT AFAEDFKDQL TSRAALVVGF
     VLVLAFALLL IVFRSLAIPL VSIALNLLSM GAAYGVLTWV FQDGAFSSVL GFTPYGGVAG
     WLPLFMFVVL FGLSMDYHIF ILSRIRERRL AGATTREAVV GGIAASAGVV TSAAVIMTAV
     FTVFITLSAI ENKMMGVGMA VAILIDATIV RGVLLPAAVA MLGERAWTLP GRLNRLNRLP
     GTSEPSRPAP VAAATGARTD
//