ID A0A101TTM7_9ACTN Unreviewed; 406 AA.
AC A0A101TTM7;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:KUN98254.1};
DE EC=2.3.1.9 {ECO:0000313|EMBL:KUN98254.1};
GN ORFNames=AQJ67_28320 {ECO:0000313|EMBL:KUN98254.1};
OS Streptomyces caeruleatus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=661399 {ECO:0000313|EMBL:KUN98254.1, ECO:0000313|Proteomes:UP000053429};
RN [1] {ECO:0000313|EMBL:KUN98254.1, ECO:0000313|Proteomes:UP000053429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-24802 {ECO:0000313|EMBL:KUN98254.1,
RC ECO:0000313|Proteomes:UP000053429};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces caeruleatus NRRL B-24802, type
RT strain for the species Streptomyces caeruleatus.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUN98254.1}.
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DR EMBL; LMWY01000037; KUN98254.1; -; Genomic_DNA.
DR RefSeq; WP_062722151.1; NZ_KQ948933.1.
DR AlphaFoldDB; A0A101TTM7; -.
DR STRING; 661399.AQJ67_28320; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000053429; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR PANTHER; PTHR43853:SF8; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:KUN98254.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053429};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:KUN98254.1}.
FT DOMAIN 5..274
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 282..404
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 90
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 361
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 391
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 406 AA; 42861 MW; 86293EDD8C2B79BC CRC64;
MPEAVIVSTA RSPIGRAFKG SLKDLRPDDL TATIIQAALA KVPELDPRDI DDLMLGCGLP
GGEQGNNLGR IVAVQMGMDH LPGCTITRYC SSSLQTSRMA LHAIKAGEGD VFISAGVEMV
SSYAKGNSDS IPDTHNPFFA EAEARTAAVA QQEGTTWHDP REDGLVPDAY IAMGQTAENL
ARSKGITRED MDEFGVRSQN LAEEAIKNGF WEREITPVTT PDGTVVSKDD GPRAGVTLEG
VQGLKPVFRP DGLVTAANCC PLNDGAAALV IMSDTKAREL GLTPLARIVS TGVSGLSPEI
MGLGPVEASQ QALRRAGLTI DDIDLVEINE AFAAQVIPSY RELGIDVDKL NVNGGAIAVG
HPFGMTGARI TTTLINSLQH HDKQFGLETM CVGGGQGMAM VIERLS
//
